Collection of Blood for Gene Expression Study in Individuals With Chronic Lung Diseases
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Purpose
This protocol is designed to gather a small amount of blood from patients seen in the New York Presbyterian Hospital-Weill Cornell Medical Center Pulmonary, Critical Care unit, and 5 West floor (Pulmonary Floor) for clinical care associated with chronic lung disease. This protocol will also survey medical records of patients with chronic lung disease, in order to study the clinical characteristics of these individuals. Investigators aim to understand the genetics of chronic lung diseases, and will use the serum and DNA from this blood to perform various genotyping studies such as such as genomic/gene expression studies of individuals with chronic lung diseases
| Condition |
|---|
|
Pulmonary Diseases |
| Study Type: | Observational |
| Official Title: | Collection of Blood for Gene Expression Study in Individuals With Chronic Lung Diseases |
| Estimated Enrollment: | 600 |
| Study Start Date: | April 2006 |
| Estimated Study Completion Date: | June 2013 |
| Estimated Primary Completion Date: | June 2013 (Final data collection date for primary outcome measure) |
This protocol is designed to gather a small amount of blood from patients seen in the New York Presbyterian Hospital-Weill Cornell Medical Center Pulmonary, Critical Care unit, and 5 West floor (Pulmonary Floor) for clinical care associated with chronic lung disease. This protocol will also survey medical records of patients with chronic lung disease, in order to study the clinical characteristics of these individuals. Investigators aim to understand the genetics of chronic lung diseases, and will use the serum and DNA from this blood to perform various genotyping studies such as such as genomic/gene expression studies of individuals with chronic lung diseases.
General admission criteria for this project will require at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and (6) patients with diseases of organs with known association with lung disease.
The following studies will be conducted on blood specimens: genomic DNA will be extracted; promoter sequences for antioxidant-related genes will be obtained by PCR and sequenced. The goal is to find single nucleotide polymorphisms (SNP) to see if they correlate with lung disease. DNA samples and blood specimens will be coded. Samples could potentially be traced back to the patient. However, every effort will be made to keep the patient's identity confidential per HIPAA regulations.
The study does not aim to create a blood bank. Rather, the blood samples will be used for DNA extraction only. Serum will be stored for future studies, to look at levels of proteins.
Eligibility| Ages Eligible for Study: | 18 Years to 90 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
General admission criteria for this project will require at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and (6) patients with diseases of organs with known association with lung disease.
Inclusion Criteria:
- Must provide informed consent
- Males and females, age 18 years and older
- Lung disease proven by at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and (6) diseases of organs with known association with lung disease
Exclusion Criteria:
- Drug and/or alcohol abuse within the past six months
- Females who are pregnant or nursing
Contacts and Locations| Contact: Charleen Hollmann, PhD, MPA, RN | 646-962-2672 | chollman@med.cornell.edu |
| United States, New York | |
| Weill Medical College of Cornell University | Recruiting |
| New York City, New York, United States, 10021 | |
| Contact: Charleen Hollmann, PhD 646-962-2672 chollman@med.cornell.edu | |
| Contact: Katrina Bandong, BA 646-962-2672 kab2036@med.cornell.edu | |
| Principal Investigator: Ronald G Crystal, MD | |
| Principal Investigator: | Ronald G. Crystal, M.D. | Weill Medical College of Cornell University |
| Study Director: | Ben-Gary Harvey, M.D. | Weill Medical College of Cornell University |
More Information
No publications provided
| Responsible Party: | Weill Medical College of Cornell University |
| ClinicalTrials.gov Identifier: | NCT00320151 History of Changes |
| Other Study ID Numbers: | Blood Collection Protocol |
| Study First Received: | April 27, 2006 |
| Last Updated: | February 22, 2013 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Weill Medical College of Cornell University:
|
chronic lung disease |
Additional relevant MeSH terms:
|
Lung Diseases Respiration Disorders Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on May 19, 2013