EEG Studies of Sensory Processing in Autistic Children

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2010 by Massachusetts General Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
CURE Foundation
The Commonwealth Fund
National Alliance for Autism Research
Nancy Lurie Marks Family Foundation
Information provided by:
Massachusetts General Hospital
ClinicalTrials.gov Identifier:
NCT00319722
First received: April 27, 2006
Last updated: May 3, 2010
Last verified: May 2010
  Purpose

This study uses EEG to study brain waves at rest and in response to specific auditory and visual sensory stimuli in autistic children. We hypothesize that, compared to same age peers, autistics will show abnormalities in their electrophysiologic processing of sounds (tones and phonemes)and visual stimuli (flashes of light)and that these abnormalities will be able to separate autistics not only from typical children but also into clinical subgroups with specific biological/electrophysiological characteristics. We hope to find biological measures which will prove diagnostic of autism in very young children and which can be used in the measurement of treatment outcome in future intervention trials.


Condition Phase
Autism
Phase 1

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Electrophysiologic Indicators of Gating and Timing Abnormalities in Autism

Resource links provided by NLM:


Further study details as provided by Massachusetts General Hospital:

Primary Outcome Measures:
  • EEG and ERP abnormalities [ Time Frame: 2 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Characteristic and severity of autistic behaviors [ Time Frame: 2 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 130
Study Start Date: February 2006
Estimated Study Completion Date: March 2011
Estimated Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   3 Months to 8 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

autistic children meeting criteria for autism based on ADOS and ADI and clinical DSM IV or their siblings between the ages of 3 months to 13 years.

Criteria

Inclusion Criteria:

autistic children or their younger siblings between the ages of 3 months to 8 year

Controls: typically developing children 3mo to 8 years without known language or social disorder and not related to child with autism

Exclusion Criteria: progressive encephalopathy, treatment with multiple antiepileptic drugs, known genetic diagnosis.

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  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00319722

Contacts
Contact: Alyssa Orinstein 617-966-9766 transcend@partners.org

Locations
United States, Massachusetts
MGH LADDERS Clinic Recruiting
Lexington, Massachusetts, United States, 02421
Contact: Katherine M. Martien, M.D.    781-860-1720    kmartien@partners.org   
Principal Investigator: Katherine M. Martien, M.D.         
Sponsors and Collaborators
Massachusetts General Hospital
CURE Foundation
The Commonwealth Fund
National Alliance for Autism Research
Nancy Lurie Marks Family Foundation
Investigators
Principal Investigator: Katherine M. Martien, M.D. Massachusetts General Hospital
Principal Investigator: Martha Herbert, M.D. Massachusetts General Hospital
  More Information

No publications provided

Responsible Party: Katherine M. Martien, M.D., Principal Investigator, Massachusetts General Hospital
ClinicalTrials.gov Identifier: NCT00319722     History of Changes
Other Study ID Numbers: 2005-P-000868/3
Study First Received: April 27, 2006
Last Updated: May 3, 2010
Health Authority: United States: Institutional Review Board

Keywords provided by Massachusetts General Hospital:
autism
pervasive developmental disorder
evoked potentials
EEG
Coherence

Additional relevant MeSH terms:
Autistic Disorder
Child Development Disorders, Pervasive
Mental Disorders Diagnosed in Childhood
Mental Disorders

ClinicalTrials.gov processed this record on August 26, 2014