Efficacy of rTMS in the Treatment of Patients With Migraine

This study is currently recruiting participants.

Verified June 2010 by Taipei Veterans General Hospital,Taiwan

First Received on April 20, 2006. Last Updated on June 6, 2010 History of Changes

Sponsor:	Taipei Veterans General Hospital,Taiwan
Collaborator:	National Science Council, Taiwan
Information provided by:	Taipei Veterans General Hospital,Taiwan
ClinicalTrials.gov Identifier:	NCT00316979

Purpose

Migraine is a condition thought to be related to cortical hyperexcitability. Repetitive transcranial magnetic stimulation (rTMS) can modulate the cortical excitability by means of long-term potentiation or long-term depression. This study will will test the safety and efficacy of rTMS in the treatment of patients with Migraine.

Condition	Intervention
Migraine	Device: Repetitive Transcranial Magnetic Stimulation (rTMS)

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Double-Blind Primary Purpose: Treatment
Official Title:	Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Migraine Using Somatosensory Evoked High-Frequency Oscillations as a Parameter: A 3-year Study.

Resource links provided by NLM:

Genetics Home Reference related topics: familial hemiplegic migraine

MedlinePlus related topics: Headache Migraine

U.S. FDA Resources

Further study details as provided by Taipei Veterans General Hospital,Taiwan:

Primary Outcome Measures:

Reduction in days of migraine attack per month

Secondary Outcome Measures:

The reduction in dosage of acute abortive medication
The reduction of headache index

Estimated Enrollment:	80
Study Start Date:	April 2006

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Age of 18-65 years
Diagnosed as migraine (with or without aura)
More than 4 attacks per month for at least 3 months prior to study
No preventive medication used
Must be able to sign permit

Exclusion Criteria:

History of seizure or family history of seizures
Women in pregnancy or breast-feeding
Patient with medication overuse
Patient with other medical, psychologic, or surgical illness
Patient under preventive medications
Prior rTMS examination one month within

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00316979

Contacts

Contact: Shuu-Jiun Wang, MD	+886-2-28712121 ext 2425	sjwang@vghtpe.gov.tw
Contact: Kuan-Lin Lai, MD	+886-2-28712121 ext 3185	kllai@vghtpe.gov.tw

Locations

Taiwan
Headache Center, Teipei Veterans General Hospital	Recruiting
Taipei, Taiwan, 112
Contact: Shuu-Jiun Wang, MD +886-2-28712121 ext 2425 sjwang@vghtpe.gov.tw
Contact: Jong-Ling Fuh, MD +886-2-28712121 ext 3256 jlfuh@vghtpe.gov.tw
Principal Investigator: Shuu-Jiun Wang, MD

Sponsors and Collaborators

Taipei Veterans General Hospital,Taiwan

National Science Council, Taiwan

Investigators

Principal Investigator:

Shuu-Jiun Wang, MD

Headache Center, Taipei Veterans General Hospital

More Information

Publications:

Brighina F, Piazza A, Vitello G, Aloisio A, Palermo A, Daniele O, Fierro B. rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J Neurol Sci. 2004 Dec 15;227(1):67-71.

Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain. 2003 May;126(Pt 5):1079-91.

ClinicalTrials.gov Identifier:	NCT00316979 History of Changes
Other Study ID Numbers:	rTMS_Migraine_VGHTPE
Study First Received:	April 20, 2006
Last Updated:	June 6, 2010
Health Authority:	Taiwan: Department of Health

Keywords provided by Taipei Veterans General Hospital,Taiwan:

migraine
transcranial magnetic stimulation
repetitive transcranial magnetic stimulation
rTMS

Additional relevant MeSH terms:

Migraine Disorders
Headache Disorders, Primary
Headache Disorders

Brain Diseases
Central Nervous System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on February 09, 2012