Advancement of Psychophysics of Pain Modulation From Lab to Clinic: Constructing Susceptibility Profile for Appearance of Postoperative Neuropathic Pain

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2007 by Rambam Health Care Campus.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Israel Scientific Foundation
Information provided by:
Rambam Health Care Campus
ClinicalTrials.gov Identifier:
NCT00305136
First received: March 19, 2006
Last updated: July 8, 2007
Last verified: June 2007
  Purpose

Recent advances in the field of pain psychophysics that have enhanced the understanding of pain processing by the nervous system seem to characterize the individual pattern of pain processing, thereby enabling the prediction of a person’s susceptibility to develop chronic pain consequent to surgery.

In this project, the researchers propose to apply a wide array of advanced testing methods in order to prospectively assess the pain modulation pattern of pain free patients about to undergo an elective thoracotomy. Since about half of post-thoracotomy patients suffer from chronic neuropathic postoperative pain, the researchers expect to identify which tests predict a risk for this pain and the relative power of the relevant tests in this prediction, and to construct a short and applicable tool, the 'pain susceptibility profile', that will reliably predict the risk for the development of pain. The expected results of this project will serve the field of pain prevention by identifying patients at risk and tailoring interventions to reduce the risk of chronic pain.


Condition
Pain, Postoperative

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Official Title: Advancement of Psychophysics of Pain Modulation From Lab to Clinic: Constructing Susceptibility Profile for Appearance of Postoperative Neuropathic Pain

Resource links provided by NLM:


Further study details as provided by Rambam Health Care Campus:

Enrollment: 130
Study Start Date: December 2005
Estimated Study Completion Date: June 2007
Detailed Description:

The common prevalence of painful syndromes following surgical interventions and injuries calls for a preventive therapeutic approach that can only be based on better insight into the pain modulation mechanisms in these patients. Recent advances in the field of pain psychophysics that have enhanced our understanding of pain processing by the nervous system seem to characterize the individual pattern of pain processing, thereby enabling the prediction of a person’s susceptibility to develop chronic pain consequent to surgery.

In this project, we propose to apply a wide array of advanced testing methods in order to prospectively assess the pain modulation pattern of pain free patients about to undergo an elective thoracotomy. Tests will include:

  1. psychophysical tests: pain thresholds and suprathreshold magnitude estimation, temporal summation, endogenous analgesia – diffuse noxious inhibitory control (DNIC);
  2. tests for the interaction between pain and the autonomic nervous system including the inhibitory effect of vagal activation on pain perception, and the response pattern of the sympatho-parasympathetic balance to noxious stimulation; and
  3. evaluation of personality components known to be associated with chronic pain including anxiety, catastrophization and somatization.

Since about half of post-thoracotomy patients suffer from chronic neuropathic postoperative pain, we expect to identify which tests predict a risk for this pain and the relative power of the relevant tests in this prediction, and to construct a short and applicable tool, the 'pain susceptibility profile', that will reliably predict the risk for the development of pain. The contribution of the above tests to the severity of acute postoperative pain, and of the latter on the development of the chronic postoperative pain will also be evaluated.

The expected results of this project will serve pain prevention by identifying patients at risk and tailoring interventions to reduce the risk of chronic pain. Also, in the wider pain research context, this understanding will allow better design and analysis of studies on pain mechanisms and therapies by considering the pain susceptibility of participating patients.

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Pain free patients to undergo major thoracic operation with both malignant and non-malignant diseases.

Exclusion Criteria:

  • Psychiatric or cognitive dysfunction precluding use of psychophysics
  • Existing thoracic pain
  • Patients who cannot communicate in Hebrew
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00305136

Locations
Israel
Rambam Medical Center
Haifa, Israel, 31096
Sponsors and Collaborators
Rambam Health Care Campus
Israel Scientific Foundation
Investigators
Principal Investigator: David Yarnitsky, Professor Neurology Department Chairman, Rambam Medical Center, Haifa, Israel
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00305136     History of Changes
Other Study ID Numbers: thoracotomyCTIL, ISF
Study First Received: March 19, 2006
Last Updated: July 8, 2007
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Rambam Health Care Campus:
thoracotomy
post-operative pain
chronic pain
endogenous analgesia
temporal summation
central sensitization
prediction
Patients Who Should Undergo Thoracotomy

Additional relevant MeSH terms:
Neuralgia
Pain, Postoperative
Disease Susceptibility
Pain
Neurologic Manifestations
Nervous System Diseases
Peripheral Nervous System Diseases
Neuromuscular Diseases
Signs and Symptoms
Postoperative Complications
Pathologic Processes
Disease Attributes

ClinicalTrials.gov processed this record on September 16, 2014