Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis.
Recruitment status was Not yet recruiting
In conventional treatment for non-complicated bacterial cystitis, 3-day oral antibiotics could achieve good cure rate. However, severe lower urinary tract symptoms were most bothersome and only could be partially relieved by NSAID, detrusor muscle relaxants, minor tranquilizer or pyridium. Some medication associated side effects were complained while receiving adjuvant medication treatment, including gastro-intestinal discomfort, dry mouth, blurred vision, lethargy, or allergic reactions. The irritative bladder symptoms from bladder inflammation had great impact on the quality of life and well tolerable adjuvant therapy would have clinical benefit to reduce the discomfort from the bladder.
In the past years, cranberry juice or its extract has been proven to have protective effect on urothelium to prevent further bacterial ascending infection. The commercial cranberry extract tablets have good tolerability and showed good effect on symptoms reliving and infection protection on several clinical observation. In acute bladder infection, we could expect the bioactive components in cranberry could reduce the virulence of pathogens and assist to eradicate pathogens and to stable the urothelium. In literature review, only little works focusing on the symptoms relief in acute cystitis patients. To clarify the clinical benefit on lower urinary symptoms relieving, we attempt to conduct a randomized double-blind placebo-controlled trial to evaluate the effect of a compound cranberry extract tablet as an adjunctive modality in treating acute uncomplicated bacterial cystitis in otherwise healthy female patients.
Urinary Tract Infections
Drug: compound cranberry extract tablet
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets (UmayC) in Acute Bacterial Cystitis.|
- Time to symptoms relief
- Pyuria eradication rate
|Study Start Date:||April 2006|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00305071
|Contact: Po-Chien Huang, MD||886-3-3179599 ext firstname.lastname@example.org|
|Contact: Hung-Ju Yang, MD||886-3-3179599 ext email@example.com|
|Min-Sheng General Hospital||Not yet recruiting|
|Taoyuan City, Taiwan, 320|
|Contact: Po-Chien Huang, MD 886-3-3179599 ext 8223 firstname.lastname@example.org|
|Principal Investigator:||Po-Chien Huang, MD||Division of Urology, department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan|