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Assessment of the Ability to Distinguish Odors in Glaucoma Patients

This study has been completed.
Sponsor:
Information provided by:
University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:
NCT00304824
First received: March 17, 2006
Last updated: September 25, 2008
Last verified: September 2008
History of Changes
  Purpose

Glaucoma is one of the leading causes of blindness worldwide. The key feature of glaucoma is damage to the optic nerve head with loss of retinal ganglion cells and local tissue remodeling. Neuronal cell death in glaucoma occurs by apoptotic mechanisms1. Apoptosis of neurons also plays a major role in neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. An association between glaucoma and these disorders has been described 2-4. Furthermore, it has been reported that the olfactory function is disturbed in these neurodegenerative diseases5-6. We hypothesize that similar olfactory alterations may occur in glaucoma which is in fact a local neurodegenerative disease.


Condition
Glaucoma

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Olfactory Function in Glaucoma Patients

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University Hospital, Basel, Switzerland:

Enrollment: 30
Study Start Date: October 2004
Study Completion Date: November 2005
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   17 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

glaucoma patients

Criteria

Inclusion Criteria:

Chronic open-angle glaucoma with typical glaucomatous disc and visual field damage.

Exclusion Criteria:

  • Occludable iridocorneal angles
  • History of current, chronic or recurrent inflammatory eye disease
  • History of retinal or neuroophthalmologic disease that could result in visual field defects
  • Need for any concomitant medications that may interfere with the evaluation of olfactory function
  • Patients with a significant history and/or active alcohol or drug abuse (significant is defined as that which in the opinion of the investigator may either put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study), smokers
  • History of olfactory disturbance related to identifiable local factors and any local condition that could lead to hyposmia/anosmia or interfere with the olfactory function, such as polyps, chronic sinus infection, sub(acute) viral or bacterial infection, history of sinus surgery
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00304824

Sponsors and Collaborators
University Hospital, Basel, Switzerland
Investigators
Study Director: Selim Orgul University Eye Hospital Basel, Switzerland
  More Information

Additional Information:
University Basel, Switzerland  This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party: Selim Orgül, MD, University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier: NCT00304824     History of Changes
Other Study ID Numbers: 009-Guk-2004-002
Study First Received: March 17, 2006
Last Updated: September 25, 2008
Health Authority: Switzerland: Swissmedic

Keywords provided by University Hospital, Basel, Switzerland:
Glaucoma
Olfactory functions
Sniffing Sticks Test

Additional relevant MeSH terms:
Glaucoma
Ocular Hypertension
Eye Diseases

ClinicalTrials.gov processed this record on May 16, 2013