Pulmonary Infections Masquerading as Community-Acquired Pneumonia
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Purpose
The purpose of this research is to identify cases from patients who have been referred for consultation to the Infectious Disease Section at the VAMC, Houston, and to compare them with other cases of CAP in order to determine whether there are features that might enable non-CAP cases to be distinguished from CAP.
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Retrospective |
| Official Title: | Pulmonary Infections Masquerading as Community-Acquired Pneumonia |
| Enrollment: | 40 |
| Study Start Date: | January 2004 |
| Study Completion Date: | January 2007 |
| Primary Completion Date: | January 2007 (Final data collection date for primary outcome measure) |
Guidelines to treat community acquired pneumonia (CAP) have been developed and widely promulgated by important professional societies in the past 10 years. The impetus to do so came from the observation that practicing physicians were using a wide array of approaches to this common infection, many of which were substandard.
The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have been leaders in this field, publishing recommendations separately between 1993 and 2003. The PI served on the IDSA committee and coauthored the publication in 2000 and the update in 2003. In 2004, a decision was made by the two professional societies to merge the committees and make a single joint set of recommendations; the PI is a member of that joint committee and a new document is being prepared for publication.
The PI has observed a tendency to apply these guidelines to cases that might masquerade as CAP but are actually attributable to other conditions, such as lung cancer, tuberculosis and histoplasmosis. Further, the recommendations do not adequately cover pneumonia due to Staphylococcus aureus.
The purpose of the research is to identify cases from the consult records of the Infectious Disease Section at the VAMC, Houston, and to compare them with other cases of CAP in order to determine whether there are features that might enable non-CAP cases to be distinguished from CAP.
Eligibility| Ages Eligible for Study: | 18 Years to 64 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patients with Pulmonary infections.
Inclusion Criteria:
- subjects who were seen in calendar year 2004 because they were thought to have CAP, but who, upon further evaluation, plainly did not, and consultation was sought.
- case control is diagnosis of CAP with verification by all or nearly all of the following features: presence of cough, increased sputum, fever, leukocytosis and a distinct new pulmonary infiltrate.
Exclusion Criteria:
- among the case controls, if the diagnosis of CAP was made despite the absence of the cardinal features of CAP, as cited above, the investigators will not include the case.
Contacts and Locations| United States, Texas | |
| Michael E. DeBakey Veterans Affairs Medical Center | |
| Houston, Texas, United States, 77030 | |
| Principal Investigator: | Daniel M Musher, M.D. | Baylor College of Medicine, Houston VA Medical Center |
More Information
No publications provided
| Responsible Party: | Daniel Musher, MD, VAHouston |
| ClinicalTrials.gov Identifier: | NCT00304395 History of Changes |
| Other Study ID Numbers: | H-17555 |
| Study First Received: | March 16, 2006 |
| Last Updated: | September 9, 2010 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by VA Medical Center, Houston:
|
Community Acquired Pneumonia CAP |
Additional relevant MeSH terms:
|
Pneumonia Lung Diseases Respiratory Tract Diseases Respiratory Tract Infections |
ClinicalTrials.gov processed this record on May 23, 2013