Changes in Brain Activity (Functional MRI Study) Before and After Behavioral Therapy of Height Phobia

This study has been completed.
Information provided by (Responsible Party):
New York State Psychiatric Institute Identifier:
First received: March 14, 2006
Last updated: December 14, 2011
Last verified: April 2007

We are interested in investigating the functional brain abnormalities of height phobia. Subjects will be have a functional MRI scan before and after a course of treatment with behavioral therapy.

Condition Intervention
Height Phobia
Fear of Heights
Behavioral: Behavior therapy

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: The Effects of in Vivo Exposure Therapy on the Neural Correlates of Height Phobia: a Functional Magnetic Resonance Imaging Study Using a Fear Provocation Paradigm.

Resource links provided by NLM:

Further study details as provided by New York State Psychiatric Institute:

Primary Outcome Measures:
  • CGI

Secondary Outcome Measures:
  • acrophobia questionnaire

Estimated Enrollment: 40
Study Start Date: March 2006
Study Completion Date: June 2006
Detailed Description:

The purpose of this study is to investigate the effects of in vivo exposure therapy on the functional brain activity of subjects with height phobia using a fear provocation paradigm. We expect differential activation of the fear circuitry in height phobics compared to non-phobic controls, and that successful behavioral therapy will normalize the heightened fear response in height phobia.


Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Specific phobia of Heights

Exclusion Criteria:

  • History of medical problems
  Contacts and Locations
Please refer to this study by its identifier: NCT00302978

Sponsors and Collaborators
New York State Psychiatric Institute
Principal Investigator: Yujuan Choy, M.D. New York State Psychiatric Institute, Columbia University
  More Information

No publications provided

Responsible Party: New York State Psychiatric Institute Identifier: NCT00302978     History of Changes
Other Study ID Numbers: 5215
Study First Received: March 14, 2006
Last Updated: December 14, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by New York State Psychiatric Institute:
Height phobia
fear of heights
specific phobia

Additional relevant MeSH terms:
Phobic Disorders
Anxiety Disorders
Mental Disorders processed this record on April 17, 2014