Etiology of Anemia

This study has been terminated.

Sponsor:

Information provided by:

National Institutes of Health Clinical Center (CC)

ClinicalTrials.gov Identifier:

NCT00302939

First received: March 14, 2006

Last updated: April 21, 2010

Last verified: April 2010

History of Changes

Purpose

This study looks at the causes of anemia in adults of all ages who are referred by their primary care physician.

Condition
Anemia

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Studies in the Etiology of Anemia in an Unselected Sequential Referral Population

Resource links provided by NLM:

MedlinePlus related topics: Anemia

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Biospecimen Retention: Samples Without DNA

Bone marrow aspirate, urine, blood serum

Estimated Enrollment:	300
Study Start Date:	January 2006
Estimated Study Completion Date:	December 2010
Estimated Primary Completion Date:	December 2010 (Final data collection date for primary outcome measure)

Detailed Description:

This study is being done to determine if the range of causes of anemia changes with advancing age. The goal of this study is to apply research methods to see if causes of anemia can be determined in patients where a clear cause is not found with routine clinical testing available to all patients in physician offices.

Participants in this study will be evaluated at the NIA-ASTRA unit at Harbor Hospital in Baltimore. Testing will consist of both diagnostic and research blood and urine testing along with history and physical exam. An optional bone marrow aspirate or aspirate and biopsy may be performed if the patient permits and it is indicated for either research or clinical diagnostic purposes. All study information supporting a specific diagnosis will be provided to the patient and, at their request, to their primary care physician if specific treatment is indicated.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Community

Criteria

Inclusion Criteria:

18 years of age or older
Hemoglobin (Hgb) less than 13 in males and females

Exclusion Criteria:

Pregnant or nursing women
Participation within the past six weeks in another research study which the Principal Investigator believes is incompatible with this study

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00302939

Locations

United States, Maryland
National Institute on Aging
Baltimore, Maryland, United States, 21225

Sponsors and Collaborators

National Institute on Aging (NIA)

Investigators

Principal Investigator:

William Ershler, MD

NIA/NIH

More Information

Publications:

Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004 Oct 15;104(8):2263-8. Epub 2004 Jul 06.

Artz AS, Fergusson D, Drinka PJ, Gerald M, Bidenbender R, Lechich A, Silverstone F, McCamish MA, Dai J, Keller E, Ershler WB. Mechanisms of unexplained anemia in the nursing home. J Am Geriatr Soc. 2004 Mar;52(3):423-7.

Responsible Party:	William B. Ershler, M.D., Principle Investigator, National Institute on Aging
ClinicalTrials.gov Identifier:	NCT00302939 History of Changes
Other Study ID Numbers:	AG0062
Study First Received:	March 14, 2006
Last Updated:	April 21, 2010
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Aging

Additional relevant MeSH terms:

Anemia
Hematologic Diseases

ClinicalTrials.gov processed this record on June 17, 2013

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