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B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients

This study has been completed.
Science, Toxicology & Technology, San Francisco, California
Information provided by:
University of Copenhagen Identifier:
First received: March 13, 2006
Last updated: NA
Last verified: December 2000
History: No changes posted

The primary aim was to measure the effect of green tea extract, tyrosine and caffeine on energy expenditure, appetite ratings and spontaneous energy intake together with recording of side effects in healthy normal weight subjects.

Condition Intervention Phase
Drug: tyrosine, green tea, caffeine
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Prevention
Official Title: B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients

Resource links provided by NLM:

Further study details as provided by University of Copenhagen:

Primary Outcome Measures:
  • heart rate
  • blood pressure
  • enegy expenditure
  • energy intake
  • subjective appetite sensations

Estimated Enrollment: 12
Study Start Date: January 2000
Estimated Study Completion Date: December 2000
Detailed Description:

Background: Long-term weight maintenance of a weight loss is often unsuccessful. Often a weight regain is observed in most studies that could indicate that most subjects are not able to change their eating habits. There is a need for simple and safe methods to prevent weight gain and re-gain i.e. by increasing thermogenesis and decrease spontaneous energy intake (EI). Studies have shown that nutritional and food-related non-nutritional factors influence the adjustment of EI and EE as the compounds can enhance the diet-induced thermogenesis (DIT) and suppress appetite.

Method: The present study was designed as a 4-way crossover, randomised, placebo controlled, dou-ble-blind study. Each treatment was separated by >3 d washout period. All treatments were administered as tablets containing either 500 mg green tea extract (whereof 125 mg cate-chins), 400 mg tyrosine, 50 mg anhydrous caffeine, or placebo.

on each test day body weight and composition was assessed. All participants underwent a 4.5-h assessment of energy expenditure by indirect calorimetry in a ventilated hood. Energy intake recorded of an ad libitum pasta salad brunch served after the last hood measurement

Subjects: Twelve healthy lean (20<BMI<25) weight stable non-smoking subjects between 18-40 years of age were tested 4 times each with a wash-out period of at least 3 days.


Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Twelve healthy and normal-weight men (age: 23.72.6 y, BMI: 22.41.8 kg/m2) participated in the study. They were weight stable (within 3-kg in last 3 mo), non-smoking, non-athletic, and had no use of dietary supplements or frequent use of medication.

Exclusion Criteria:


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Please refer to this study by its identifier: NCT00302289

Department of Human Nutrition, The Royal Veterinary and Agricultural University
Frederiksberg, Denmark, 1958
Sponsors and Collaborators
University of Copenhagen
Science, Toxicology & Technology, San Francisco, California
Principal Investigator: Astrup Arne, Prof Department of Human Nutrition, The Royal Veterinary and Agricultural University, Denmark
  More Information

No publications provided Identifier: NCT00302289     History of Changes
Other Study ID Numbers: KF01-188/00
Study First Received: March 13, 2006
Last Updated: March 13, 2006
Health Authority: Denmark: The Danish National Committee on Biomedical Research Ethics

Keywords provided by University of Copenhagen:
green tea
energy expenditure
energy intake processed this record on November 23, 2014