X-Chromosome Inactivation Status and Premature Ovarian Failure
Recruitment status was Active, not recruiting
Women who are affected with premature ovarian failure will exhibit skewed X-chromosome inactivation patterns compared to women with normal menstrual function (as defined by being pregnant), indicating a possible X-chromosome defect.
Premature Ovarian Failure
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||X-Chromosome Inactivation Status and Premature Ovarian Failure|
DNA that is extarcted from the blood specimen
|Study Start Date:||November 2005|
|Estimated Study Completion Date:||May 2009|
|Estimated Primary Completion Date:||November 2008 (Final data collection date for primary outcome measure)|
Premature ovarian failure (POF) affects approximately 1% of women. For most women a cause is not found, but structural abnormalities of the X-chromosome commonly lead to POF, suggesting genes on the X-chromosome are necessary for normal ovarian function. It is known that certain gene mutations on the X-chromosome can lead to changes in the normal random pattern of X-chromosome inactivation in females.
We propose to study X-inactivation patterns in a cohort of women with idiopathic POF, and compare their pattern to a mean age-matched cohort of women with normal menstrual function.
We hypothesize that some women with POF will show skewed X-inactivation, suggesting a mutation on the X-chromosome as the etiology of their POF.
|United States, Pennsylvania|
|Pittsburgh, Pennsylvania, United States, 15213|
|Principal Investigator:||W. Allen Hogge, MD||University of Pittsburgh and Magee-Womens Hospital|