Clofarabine and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia, or Myeloproliferative Disorders

DISEASE CHARACTERISTICS:

• Histologically confirmed leukemia or myeloproliferative disorders, including 1 of the following:

  • Acute myeloid leukemia (AML) of any subtype

    • Treatment-related AML OR AML evolving from myeloproliferative disorders (MPD) or transformed from myelodysplastic syndrome
  • Acute lymphocytic leukemia

  • Acute progranulocytic leukemia

    • Must not be eligible for arsenic or retinoic acid therapy
  • Chronic myelogenous leukemia in accelerated phase or blast crisis

  • High-risk MPD, including any of the following:

    • Myelofibrosis
    • Chronic myelomonocytic leukemia with 5%-19% blasts
    • Relapsed or refractory juvenile myelomonocytic leukemia

• Relapsed and/or refractory disease with progressive disease since last therapy

  • No more than 3 prior induction regimens with cytotoxic agents for adults
  • Must be in second relapse for patients < 21 years of age

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2 (for adults) OR Lansky 50-100% (for pediatric patients)
• Bilirubin ≤ 1.5 mg/dL (may be elevated due to hemolysis in adult patients)
• AST and ALT ≤ 5 times upper limit of normal
• Creatinine ≤ 2.0 mg/dL (for adults)
• Normal renal function (for pediatric patients)
• Cardiac function normal as measured by MUGA scan or echocardiogram
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier contraception during and for at least 6 months after completion of study treatment
• HIV negative
• No active graft-versus-host disease ≥ grade 2
• No active, uncontrolled infection
• No fever
• No unstable CT scans of the lungs, sinuses, or abdomen within the past 4 weeks
• No arrhythmias (other than atrial flutter or fibrillation) requiring medication
• No dyspnea at rest or with minimal exertion
• No uncontrolled congestive heart failure
• No myocardial infarction within the past 3 months
• No history of severe coronary artery disease
• No other significant concurrent disease, illness, or psychiatric disorder that would compromise patient safety or compliance or interfere with consent, study participation, follow up, or interpretation of study results

PRIOR CONCURRENT THERAPY:

• Must have recovered from all acute toxic effects from prior treatment
• More than 30 days since prior investigational cytotoxic agents
• At least 3 days since prior azacitidine, thalidomide, hydroxyurea, imatinib mesylate, or interferon
• At least 1 week since prior growth factors except epoetin alfa
• More than 3 weeks since any other prior anticancer therapy
• No concurrent chemotherapy, radiotherapy, or immunotherapy
• No other concurrent anticancer investigational or commercial agents

• No routine prophylactic use of a colony-stimulating factor (filgrastim [G-CSF] or sargramostim [GM-CSF])

  • Therapeutic use of colony-stimulating factors may be considered at the discretion of the investigator
• No prolonged use of corticosteroids to prevent or treat emesis or as a chemotherapeutic agent