Natural History Study of Moles and Suspicious Melanoma
This study has been completed.
Information provided by:
National Institutes of Health Clinical Center (CC)
First received: February 8, 2006
Last updated: November 1, 2011
Last verified: October 2011
Show Detailed Description
- Melanocytic nevi, or "moles," are non-cancerous growths of a type of skin cell called a melanocyte.
- Large congenital melanocytic nevi (LCMN) are a special type of mole that begins to grow before birth and is larger than moles that develop after birth.
- Determining how melanocytes in moles and LCMNs differ from normal melanocytes may increase the ability to predict whether a mole will give rise to a melanoma (a type of skin cancer)
- To understand how melanomas develop, by studying moles, LCMNs, and pigmented skin lesions that are suspicious for melanoma
- To develop better criteria for diagnosing melanoma, particularly by using a device called a digital dermatoscope (a special camera, connected to a computer, that takes pictures of moles when they are magnified and illuminated)
- Children 5 years old or older with an LCMN
- Adults 18 years old or older with 100 or more moles larger than 2 mm in diameter and at least one 4 mm or more
- Adults 18 years old or older with a pigmented lesion suspicious for melanoma
- Patients' personal and family health history is obtained.
- Patients are examined by investigative team doctors, and several lesions are examined with a dermatoscope.
- Additional photographs of part or all of the skin surface may be taken.
- Some lesions may be biopsied.
- Additional tests or examinations may be recommended.
- Patients are followed periodically for skin or physical examinations, photography, laboratory and imaging evaluations, and possible skin biopsies.
- Children may undergo brain magnetic resonance imaging (MRI)
Acquired Melanocytic Nevi
Primary Cutaneous Melanoma
|Official Title:||Dermoscopic Diagnosis, Histopathological Correlation, and Cellular Immortalization of Melanocytic Nevi and Primary Cutaneous Melanoma|
Resource links provided by NLM:
U.S. FDA Resources
Further study details as provided by National Institutes of Health Clinical Center (CC):
|Study Start Date:||February 2006|
|Estimated Study Completion Date:||October 2011|
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00288938
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
Sponsors and Collaborators