fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating (METRAPI)
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Purpose
Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal memory, and difficulty in regulating memories surrounding the traumatic event. A previous study (El Hage et al. Cognitive Neuropsychiatry, 2006) revealed that the trauma-exposed subjects scored higher on anxiety/depression scales, and lower on processing speed tests. Moreover, the study showed significant impairment in working memory partially mediated by speed processing, but not by anxiety or depression. These results suggest that processing speed makes a major contribution to trauma-related working memory decline, and needs to be investigated in further studies.The aim of the present study is to explore correlation between hippocampus volume, frontal dysfunction and cognitive slowing in trauma-exposed subjects, while examining brain activation during performance of working memory tasks using functional magnetic resonance.
| Condition | Intervention |
|---|---|
|
Post-Traumatic Stress Disorders Anxiety Amnesia, Dissociative |
Procedure: Magnetic Resonance Imaging, Functional |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Working Memory Updating in Posttraumatic Stress Disorder (PTSD): Study of Neural Correlates Using fMRI |
| Enrollment: | 34 |
| Study Start Date: | January 2007 |
| Study Completion Date: | May 2008 |
| Primary Completion Date: | May 2008 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| PTSD |
Procedure: Magnetic Resonance Imaging, Functional
Structural and functional MRI
|
| CONTROLS |
Procedure: Magnetic Resonance Imaging, Functional
Structural and functional MRI
|
Detailed Description:
Working memory performance will be assessed using the "3-back test", and processing speed evaluated with "words comparison test". The study will be conducted on 2 years. The study should include 18 right-handed females victims of sexual abuse and suffering from PTSD, and 18 controls right-handed females without any history of abuse ad not suffering from PTSD. Brain activation will be measured during performance of working memory tasks (3-back test) and processing speed test using functional magnetic resonance.
Eligibility| Ages Eligible for Study: | 18 Years to 40 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
PTSD related to sexual abuse vs controls, in right-handed females.
Inclusion Criteria:
- Right-handed women
- Victim of sexual abuse
- Suffering from PTSD
Exclusion Criteria:
- Epilepsy
- Claustrophobia
- MRI contre-indication
- Addictive disorders
- Sightless
- Detection of a brain injury at the MRI
Contacts and Locations More Information
Publications:
| Responsible Party: | PHRR, CHRU TOURS |
| ClinicalTrials.gov Identifier: | NCT00288314 History of Changes |
| Other Study ID Numbers: | PHRR04-WEH/METRAPI |
| Study First Received: | February 3, 2006 |
| Last Updated: | March 16, 2010 |
| Health Authority: | France: National Consultative Ethics Committee for Health and Life Sciences |
Keywords provided by University Hospital, Tours:
|
PTSD MRI, Functional Anxiety Working Memory Processing speed |
Additional relevant MeSH terms:
|
Amnesia Anxiety Disorders Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Memory Disorders Neurobehavioral Manifestations |
Neurologic Manifestations Nervous System Diseases Signs and Symptoms Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders |
ClinicalTrials.gov processed this record on May 21, 2013