fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating (METRAPI)

This study has been completed.
Sponsor:
Information provided by:
University Hospital, Tours
ClinicalTrials.gov Identifier:
NCT00288314
First received: February 3, 2006
Last updated: March 16, 2010
Last verified: March 2010
  Purpose

Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal memory, and difficulty in regulating memories surrounding the traumatic event. A previous study (El Hage et al. Cognitive Neuropsychiatry, 2006) revealed that the trauma-exposed subjects scored higher on anxiety/depression scales, and lower on processing speed tests. Moreover, the study showed significant impairment in working memory partially mediated by speed processing, but not by anxiety or depression. These results suggest that processing speed makes a major contribution to trauma-related working memory decline, and needs to be investigated in further studies.The aim of the present study is to explore correlation between hippocampus volume, frontal dysfunction and cognitive slowing in trauma-exposed subjects, while examining brain activation during performance of working memory tasks using functional magnetic resonance.


Condition Intervention
Post-Traumatic Stress Disorders
Anxiety
Amnesia, Dissociative
Procedure: Magnetic Resonance Imaging, Functional

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Working Memory Updating in Posttraumatic Stress Disorder (PTSD): Study of Neural Correlates Using fMRI

Resource links provided by NLM:


Further study details as provided by University Hospital, Tours:

Enrollment: 34
Study Start Date: January 2007
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
PTSD Procedure: Magnetic Resonance Imaging, Functional
Structural and functional MRI
CONTROLS Procedure: Magnetic Resonance Imaging, Functional
Structural and functional MRI

Detailed Description:

Working memory performance will be assessed using the "3-back test", and processing speed evaluated with "words comparison test". The study will be conducted on 2 years. The study should include 18 right-handed females victims of sexual abuse and suffering from PTSD, and 18 controls right-handed females without any history of abuse ad not suffering from PTSD. Brain activation will be measured during performance of working memory tasks (3-back test) and processing speed test using functional magnetic resonance.

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

PTSD related to sexual abuse vs controls, in right-handed females.

Criteria

Inclusion Criteria:

  • Right-handed women
  • Victim of sexual abuse
  • Suffering from PTSD

Exclusion Criteria:

  • Epilepsy
  • Claustrophobia
  • MRI contre-indication
  • Addictive disorders
  • Sightless
  • Detection of a brain injury at the MRI
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00288314

Locations
France
University Hospital of Tours
Tours, Centre, France, 37044
Sponsors and Collaborators
University Hospital, Tours
Investigators
Principal Investigator: Wissam EL HAGE, MD, PhD UNIVERSITY HOSPITAL OF TOURS
  More Information

Publications:
Responsible Party: PHRR, CHRU TOURS
ClinicalTrials.gov Identifier: NCT00288314     History of Changes
Other Study ID Numbers: PHRR04-WEH/METRAPI
Study First Received: February 3, 2006
Last Updated: March 16, 2010
Health Authority: France: National Consultative Ethics Committee for Health and Life Sciences

Keywords provided by University Hospital, Tours:
PTSD
MRI, Functional
Anxiety
Working Memory
Processing speed

Additional relevant MeSH terms:
Amnesia
Disease
Stress Disorders, Post-Traumatic
Stress Disorders, Traumatic
Anxiety Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Memory Disorders
Mental Disorders
Nervous System Diseases
Neurobehavioral Manifestations
Neurologic Manifestations
Pathologic Processes
Signs and Symptoms

ClinicalTrials.gov processed this record on October 29, 2014