Trial record 5 of 66 for:    Open Studies | Exclude Unknown | digestive disease | NIDDK

Familial Barrett's Esophagus (FBE)

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2013 by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Sponsor:
Collaborators:
University Hospital Case Medical Center
Case Western Reserve University
Creighton University Medical Center
Washington University School of Medicine
Fred Hutchinson Cancer Research Center
University of Washington
Mercy Medical Center
Johns Hopkins University
Mayo Clinic
University of North Carolina, Chapel Hill
The Cleveland Clinic
University of Pennsylvania
Columbia University
Information provided by (Responsible Party):
Amitabh Chak, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:
NCT00288119
First received: February 6, 2006
Last updated: January 15, 2013
Last verified: January 2013
  Purpose

This is a multi-center study whose aim is to define the epidemiology and genetics of Barrett's esophagus and adenocarcinoma. The researchers have studied families affected with Barrett's esophagus and esophageal adenocarcinoma, a specific type of cancer of the esophagus. They have found that Barrett's and esophageal cancer occur at a younger age in these families suggesting that familial Barrett's esophagus is a genetically inherited disease.


Condition
Barrett's Esophagus
Esophageal Neoplasm

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Cross-Sectional
Official Title: Familial Barrett's Esophagus

Resource links provided by NLM:


Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Biospecimen Retention:   Samples With DNA

Blood Samples are required to be sent to our NIH approved Biorepository and this repository is designed to help all researchers performing studies on the genetic basis of diseases.


Estimated Enrollment: 1000
Study Start Date: October 2005
Estimated Study Completion Date: September 2017
Estimated Primary Completion Date: September 2017 (Final data collection date for primary outcome measure)
Detailed Description:

This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland and the Cleveland Clinic are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Individuals with Barrett's esophagus or adenocarcenoma of the esophagus whose medical care is at the participating institutions, are referred from outside institutions, or who contact the participating institutions.

Criteria

Eligible cases will be defined as those patients and their family members who meet the following criteria:

  • Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.
  • Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.
  • Ability to give informed consent, if patient is age 18 or older.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00288119

Contacts
Contact: Amitabh Chak, MD 216-844-5385 axc22@po.cwru.edu
Contact: Wendy Brock, RN 216-844-3853 wendy.brock@UHhospitals.org

Locations
United States, Maryland
Johns Hopkins Hospital Recruiting
Baltimore, Maryland, United States, 21205
Contact: Marcia Canto, M.D.    410-614-5388      
Contact: Hilary Cosby, RN    (410) 502-2893    Hcosby1@jhmi.edu   
Principal Investigator: Marcia I Canto, M.D.         
United States, Minnesota
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Ganapathy A Prasad, M.D.    507-255-6930    Prasad.Ganapathy@Mayo.edu   
Contact: Kelly Dunagan    (507) 255-8692    Dunagan.Kelly@Mayo.edu   
Principal Investigator: Ganapathy A Prasad, M.D.         
United States, Missouri
Washington University School of Medicine Recruiting
St Louis, Missouri, United States, 63110
Contact: Jean Wang, MD    314-362-5952    jwang@DOM.wustl.edu   
Contact: Thomas Hollander    314-747-1973    tholland@DOM.wustl.edu   
Principal Investigator: Jean Wang, MD         
United States, Nebraska
Creighton University Medical Center Recruiting
Omaha, Nebraska, United States, 68131
Contact: Sumeet Mittal, MD    402-280-4161    SumeetMittal@creighton.edu   
Contact: Beth Gifford    (402) 280-4278    ElizabethGifford@Creighton.edu   
Principal Investigator: Sumeet Mittal, MD         
United States, New York
Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Julian Abrams, MD    212-342-0476    ja660@mail.cumc.columbia.edu   
Contact: Adriana Rodriquez    212-304-5606      
Principal Investigator: Julian Abrams, MD         
United States, North Carolina
University of North Carolina at Chapel Hill Recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Nicholas J Shaheen, M.D.    919-966-2513    nshaheen@med.unc.edu   
Contact: Jessica Hores    (919) 843-9616    jessica_hores@med.unc.edu   
Principal Investigator: Nicholas J Shaheen, M.D.         
United States, Ohio
Northeastern Ohio University College of Medicine, Mercy Medical Center Recruiting
Canton, Ohio, United States, 44718
Contact: James King, MD    330-305-2020 ext 465    jfjk@aol.com   
Contact: Linda Chessler    330-936-5815    craigo16@juno.com   
Principal Investigator: James King, MD         
Cleveland Veterans Administration Medical Center - Wade Park Recruiting
Cleveland, Ohio, United States, 44106
Contact: Margaret Kinnard, MD    216-791-3800 ext 3769    Margaret.kinnard@med.va.gov   
Contact: Bronia Alashkar    216-791-3800 ext 3695    bronia.alashkar@va.gov   
Principal Investigator: Margaret Kinnard, MD         
University Hospitals of Cleveland Recruiting
Cleveland, Ohio, United States, 44106-8066
Contact: Amitabh Chak, MD    216-844-5386    axc22@po.cwru.edu   
Contact: Wendy Brock, RN    216-844-3853    wendy.brock@UHhospitals.org   
Principal Investigator: Amitabh Chak, MD         
Sub-Investigator: John Dumot, MD         
The Cleveland Clinic Recruiting
Cleveland, Ohio, United States, 44195
Contact: John Vargo, MD    216-444-1000    jvargo@ccf.org   
Principal Investigator: John Vargo, MD         
United States, Pennsylvania
University of Pennsylvania Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Gary W Falk, MD, MS    215-615-6588    Gary.Falk@uphs.upenn.edu   
Contact: Maureen Demarshall, RN    215-349-8546    demarchm@mail.upenn.edu   
Principal Investigator: Gary W. Falk, MD, MS         
United States, Washington
Fred Hutchinson Cancer Research Center, UWMC Recruiting
Seattle, Washington, United States, 98109
Contact: William Grady, MD    206-667-1107    wgrady@fhcrc.org   
Contact: Kasey Orlowski    206-667-1997    Korlowsk@fhcrc.org   
Principal Investigator: William Grady, MD         
Principal Investigator: Brain Reid, MD         
Sponsors and Collaborators
University Hospital Case Medical Center
Case Western Reserve University
Creighton University Medical Center
Washington University School of Medicine
Fred Hutchinson Cancer Research Center
University of Washington
Mercy Medical Center
Johns Hopkins University
Mayo Clinic
University of North Carolina, Chapel Hill
The Cleveland Clinic
University of Pennsylvania
Columbia University
Investigators
Principal Investigator: Amitabh Chak, MD University Hospitals of Cleveland, CWRU, Cleveland, OH
Principal Investigator: Gary W Falk, MD, MS University of Pennsylvania
Principal Investigator: William Grady, MD Fred Hutchinson Cancer Research Center, UWMC, Seattle, WA
Principal Investigator: James King, MD Northeastern Ohio University College of Medicine, Mercy Medical Center, Canton, OH
Principal Investigator: Margaret Kinnard, MD VA Medical Center - Wade Park
Principal Investigator: Sumeet Mittal, M.D. Creighton University Medical Center
Principal Investigator: Nicholas J Shaheen, M.D. University of North Carolina, Chapel Hill
Principal Investigator: Ganapathy Prasad, M.D. Mayo Clinic
Principal Investigator: Marcia Canto, M.D. Johns Hopkins University
Principal Investigator: John Dumont, M.D. University Hospital Case Medical Center
Principal Investigator: John Vargo, M.D. The Cleveland Clinic
Principal Investigator: Rom Leidner, Ph.D. Case Western Reserve University
Principal Investigator: Jean Wang, MD Washington University School of Medicine
Principal Investigator: Julian Abrams, MD Columbia University
  More Information

No publications provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Amitabh Chak, Dr. Amitabh Chak, M.D., Prinicipal Investigator Dr. Gary Falk, M.D. , MS Principal Investigator, Familial Barrett's Esophagus Consortium., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier: NCT00288119     History of Changes
Other Study ID Numbers: RO1DK070863, NIH IK24DK02800
Study First Received: February 6, 2006
Last Updated: January 15, 2013
Health Authority: United States: Federal Government

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
Barrett's Esophagus

Additional relevant MeSH terms:
Digestive System Abnormalities
Digestive System Diseases
Digestive System Neoplasms
Esophageal Diseases
Gastrointestinal Diseases
Barrett Esophagus
Esophageal Neoplasms
Gastrointestinal Neoplasms
Head and Neck Neoplasms
Neoplasms
Neoplasms by Site

ClinicalTrials.gov processed this record on October 23, 2014