Autoimmune Hepatitis Study

This study has been terminated.
(Principal Investigator moving out of state, no other staff to lead research.)
Sponsor:
Collaborator:
Information provided by:
University of Rochester
ClinicalTrials.gov Identifier:
NCT00286663
First received: February 1, 2006
Last updated: July 8, 2008
Last verified: July 2008
  Purpose

The purpose of the study is to determine the role special antibodies play in possibly identifying Autoimmune Hepatitis through the following:

Identify the response of specific T cells to antibodies and Monitor the response of the cells that regulate the immune system


Condition Phase
Hepatitis, Autoimmune
Phase 1

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Evaluation of the Cellular Immune Response in Patients With Anti-SLA/LP- or Anti-LKM-Positive Autoimmune Hepatitis

Resource links provided by NLM:


Further study details as provided by University of Rochester:

Estimated Enrollment: 100
Study Start Date: January 2006
Study Completion Date: June 2008
Detailed Description:

The object of this protocol is to characterize and monitor auto antigen-specific T cell responses in blood and liver biopsies of patients with anti-SLA/LP or anti-LKM-positive autoimmune hepatitis. The results will provide insight into the pathogenesis of autoimmune hepatitis and the monitoring of auto antigen-specific T cell reactivity in correlation to disease exacerbation and therapy.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Male or female subjects,All ethnic groups, Over 18 years of age, anti-SLA/LP or anti-LKM-positive autoimmune hepatitis

Exclusion Criteria:

Subjects with a hematocrit of <25

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00286663

Sponsors and Collaborators
University of Rochester
Investigators
Principal Investigator: Parvez S Mantry, MD University of Rochester
  More Information

No publications provided

Responsible Party: Parvez S. Mantry, MD, University of Rochester Medical Center Liver and Digestive Disease Unit
ClinicalTrials.gov Identifier: NCT00286663     History of Changes
Other Study ID Numbers: RSRB 12494
Study First Received: February 1, 2006
Last Updated: July 8, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by University of Rochester:
AIH, Autoimmune Hepatitis

Additional relevant MeSH terms:
Hepatitis, Autoimmune
Autoimmune Diseases
Hepatitis
Hepatitis A
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Hepatitis, Chronic
Immune System Diseases

ClinicalTrials.gov processed this record on April 22, 2014