Ethnic Differences in the Inflammatory Response in Systemic Inflammation
The purpose of this study is to investigate putative ethnic differences in the proinflammatory response in human endotoxemia.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Educational/Counseling/Training
|Official Title:||Ethnic Differences in the Inflammatory Response in Systemic Inflammation|
- neutrophil counts
- various inflammation and coagulation parameters
- Adverse events
|Study Start Date:||January 2006|
|Estimated Study Completion Date:||April 2006|
Recent data show that there are significant disparities among genders and races in the incidence of sepsis. While men are consistently more likely to have sepsis than women, the apparent racial disparities are even more striking, approaching a doubling of the risk for sepsis among Afro-Americans. Most prominent is the risk among black men, the group in which sepsis occurs at the youngest age and results in the most deaths. Potential mechanisms for heterogeneous susceptibility to sepsis include genetic differences, which have been explored according to sex but not according to race, and other social and clinical factors.
The goal of this study is to explore whether proinflammatory and procoagulant responses in a well standardised inflammation model are comparable in healthy Caucasian and African volunteers.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00284869
|Medical University of Vienna, Dept. of Clinical Pharmacology|
|Vienna, Austria, 1090|
|Principal Investigator:||Christa Firbas, MD||Medical University of Vienna, Department of Clinical Pharmacology|