The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation
Recruitment status was Active, not recruiting
The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.
Lung Transplant Recipients
Device: Celsior Cold Storage Solution
|Official Title:||A Prospective, Controlled, Randomized Study on the Effect of Cold Storage Solutions on Complement Activation and Other Mediators of Ischemic Injury in Lung Transplantation|
|Study Start Date:||December 2000|
|Estimated Study Completion Date:||September 2005|
The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.