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PEEP Test and Gas Exchange in ALI/ARDS Patients

This study has been completed.
Sponsor:
Information provided by:
Policlinico Hospital
ClinicalTrials.gov Identifier:
NCT00284102
First received: January 30, 2006
Last updated: September 24, 2008
Last verified: September 2008
History of Changes
  Purpose

The investigators aim to study the effect of different levels of PEEP in ALI/ARDS patients on gas exchange.


Condition Intervention
Acute Respiratory Distress Syndrome
 Procedure: Mechanical ventilation

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Positive End Expiratory Pressure (PEEP) Test and Gas Exchange in ALI/ARDS Patients

Resource links provided by NLM:

MedlinePlus related topics: Gas
U.S. FDA Resources

Further study details as provided by Policlinico Hospital:

Primary Outcome Measures:
  • Gas exchange, dead space, respiratory mechanics [ Time Frame: 5, 15, 30, 60 minutes from PEEP change ] [ Designated as safety issue: No ]

Enrollment: 50
Study Start Date: January 2006
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
ALI/ARDS patients
 Procedure: Mechanical ventilation
measurement of gas exchange, dead space, respiratory mechanics 5, 15, 30, 60 minutes from PEEP change (5 and 15 cmH2O)

Detailed Description:

In a population of ALI/ARDS patients during mechanical ventilation we will evaluate the effect of different levels of PEEP on gas exchange and dead space.

  Eligibility

Ages Eligible for Study:   16 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ALI/ARDS patients requiring mechanical ventilation

Exclusion Criteria:

  • Hemodynamic instability
  • Barotrauma
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00284102

Locations
Italy
Policlinico Hospital
Milano, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Investigators
Principal Investigator: Davide Chiumello, MD Policlinico Hospital
  More Information

No publications provided

Responsible Party: Davide Chiumello, Policlinico Hospital
ClinicalTrials.gov Identifier: NCT00284102     History of Changes
Other Study ID Numbers: 1700
Study First Received: January 30, 2006
Last Updated: September 24, 2008
Health Authority: Italy: Ministry of Health

Keywords provided by Policlinico Hospital:
gas exchange
dead space
respiratory failure
ALI/ARDS patients

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Lung Diseases
Respiratory Tract Diseases
 Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury

ClinicalTrials.gov processed this record on May 16, 2013