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Effect of Exercise Intervention on Various Physiologic Factors That Change With Increasing Age

This study has been completed.
Sponsor:
Information provided by:
Mayo Clinic
ClinicalTrials.gov Identifier:
NCT00283673
First received: January 27, 2006
Last updated: June 3, 2011
Last verified: June 2011
History of Changes
  Purpose

This study randomized healthy sedentary people age 20-80 years to 16 weeks of supervised exercise versus no exercise. Several end points were evaluated after 16 weeks including insulin sensitivity and muscle physiology.


Condition Intervention
Aging
 Behavioral: Exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Official Title: Impact of Aerobic Exercise Training on Age Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Mayo Clinic:

Primary Outcome Measures:
  • Insulin sensitivity

Secondary Outcome Measures:
  • Muscle Mitochondrial Protein Synthesis
  • mRNA of mitochondrial genes
  • mRNA of genes involved in mitochondrial biogenesis

Estimated Enrollment: 102
Study Start Date: September 1995
Study Completion Date: January 1998
Primary Completion Date: January 1998 (Final data collection date for primary outcome measure)
Detailed Description:

Healthy subjects performing < 30 min exercise twice per week were studied prior to randomization and after of sixteen weeks exercise. They were randomized to sixteen weeks of supervised exercise performed on a stationary bike vs. placebo exercise (a series of flexibility exercises performed at home). Intensity, duration and frequency of exercise were gradually increased to four sessions per week lasting forty minutes each and achieving 80% target heart rate. Participants were weighed perioidically and counseled appropriately when weight changed by > 2 %. Insulin sensitivity and muscle mitochondrial protein synthesis were studied.

  Eligibility

Ages Eligible for Study:   20 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Healthy subjects performing < 30 min exercise twice per week. Age 20-90 years. Willing to be randomized to exercise versus no exercise. Willing to be studied in General Clinical Research Center with studies including Muscle Biopsy.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00283673

Locations
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Investigators
Principal Investigator: K. Sreekumaran Nair, M.D. Mayo Clinic
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00283673     History of Changes
Other Study ID Numbers: 350-95, RO1AG09531
Study First Received: January 27, 2006
Last Updated: June 3, 2011
Health Authority: United States: Institutional Review Board

ClinicalTrials.gov processed this record on May 23, 2013