MR Assessment of Brain Function Altered by Lead Exposure

This study has been completed.
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00283647
First received: January 27, 2006
Last updated: NA
Last verified: January 2006
History: No changes posted
  Purpose

Exposure to lead during pregnancy, infancy, and childhood increases the individual likelihood of impaired school performance, increased impulsiveness, aggression, and delinquent behavior. Disorders that result from exposure to environmental neurotoxicants are a complex web of interactions between genetic, neurochemical, biochemical, environmental and social factors that influence children during critical periods of development. To date, research in the area of human developmental neurotoxicology focuses primarily on global measures of sensory-motor development and cognition. However, studies elucidating the biological basis for developmental and behavioral disorders due to environmental toxicant exposure are lacking. Although gross brain structure appears normal, underlying problems exist at a neural level. Our proposal seeks to relate childhood environmental lead exposure at various levels and stages of development with detriments in brain structure and neurochemical functioning assessed with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Cortical and subcortical brain volumes will be determined with high resolution MRI. Neuronal and glial cell markers will be measured using proton MRS. These structural and chemical measures will also be correlated with behavioral measures from the young adult participants of the Cincinnati Lead Study (CLS). These participants represent a unique and ideal cohort of approximately 240 subjects with detailed histories of exposure and behavioral outcomes in lead exposed children monitored for approximately 20 years. A pilot study examining language, working memory and attention in combination with functional magnetic resonance imaging (fMRI) will also be performed to better understand the functional and behavioral deficits.


Condition
Lead Exposure

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Cross-Sectional
Official Title: MR Assessment of Brain Function Altered by Lead Exposure

Resource links provided by NLM:


Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 150
Study Start Date: October 2002
Estimated Study Completion Date: September 2006
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   19 Years to 26 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Participant in the Cincinnati Lead Study.
  2. Age range of at least 18 years with an upper limit of 25 years.
  3. Negative history for metabolic, neurologic, cardiac disease.
  4. Negative family history for metabolic or neurologic disease (in first-degree relatives only) to include genetic disorders.

Exclusion Criteria:

  1. Presence of an implant such as a hearing aid, cochlear implant, pacemaker or neuro-stimulator containing electrical circuitry or generating electrical signals or having moving metal parts.
  2. Presence of metal implants, orthopedic pins or plates above the level of the waist.
  3. Presence of orthodontic braces.
  4. Subjects who demonstrate or express noticeable anxiety and/or cannot readily communicate with personnel operating the MR equipment will be excluded.
  5. Pregnancy.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00283647

Locations
United States, Ohio
Cincinnati Children's Hospital Medical Center, Dept. of Radiology and the Imaging Research Center
Cincinnati, Ohio, United States, 45229
Sponsors and Collaborators
Investigators
Principal Investigator: Kim M Cecil, PhD Children's Hospital Medical Center, Cincinnati
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00283647     History of Changes
Other Study ID Numbers: 11261-CP-004
Study First Received: January 27, 2006
Last Updated: January 27, 2006
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
lead exposure
magnetic resonance imaging
magnetic resonance spectroscopy
functional magnetic resonance
brain development

ClinicalTrials.gov processed this record on August 28, 2014