Oligodendrocyte Progenitor Cell Culture From Human Brain

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2008 by Rajavithi Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Rajavithi Hospital
ClinicalTrials.gov Identifier:
NCT00283023
First received: January 25, 2006
Last updated: August 2, 2008
Last verified: August 2008
  Purpose

Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.


Condition Intervention Phase
Demyelinating Diseases
Procedure: Oligodendrocyte progenitor cell culture/craniotomy
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Phase 1: Oligodendrocyte Progenitor Cell Culture From Human Brain

Further study details as provided by Rajavithi Hospital:

Primary Outcome Measures:
  • Number of oligodendrocyte progenitor cell differentiation [ Time Frame: one month ] [ Designated as safety issue: No ]

Estimated Enrollment: 100
Study Start Date: December 2007
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A
Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.
Procedure: Oligodendrocyte progenitor cell culture/craniotomy
Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply
Other Name: Rajavithi Oligodendrocyte progenitor cell culture protocol

Detailed Description:

Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.

  Eligibility

Ages Eligible for Study:   20 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Male or female 20-65 years of age
  • Informed consent
  • Has elective craniotomy surgery

Exclusion Criteria:

  • HIV, hepatitis, and other central nervous system (CNS) infections
  • Dementia, Alzheimer disease, and neurodegenerative disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00283023

Contacts
Contact: Subsai Kongsaengdao, M.D. +66-6-6596159 skhongsa@gmail.com

Locations
Thailand
Assistant Professor Subsai Kongsaengdao Recruiting
Bangkok, Thailand, 10400
Contact: Subsai Kongsaengdao, M.D.    66-86-6596159    skhongsa@gmail.com   
Contact: Piyathida Boontee, M.D.    66-81-8423854    pboontee@yahoo.com   
Sponsors and Collaborators
Rajavithi Hospital
Investigators
Principal Investigator: Subsai Kongsaengdao, M.D. Division of Neurology, Department of Medicine, Rajavithi Hospital : Thailand
  More Information

No publications provided

Responsible Party: Assistant Professor Subsai Kongsaengdao, Rajavithi Hospital
ClinicalTrials.gov Identifier: NCT00283023     History of Changes
Other Study ID Numbers: RH-CMR-003, RVH-CMR-003 grant
Study First Received: January 25, 2006
Last Updated: August 2, 2008
Health Authority: Thailand: Ministry of Public Health

Keywords provided by Rajavithi Hospital:
All selective craniotomy

Additional relevant MeSH terms:
Demyelinating Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on September 16, 2014