Oligodendrocyte Progenitor Cell Culture From Human Brain
The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2008 by Rajavithi Hospital.
Recruitment status was Recruiting
Recruitment status was Recruiting
Sponsor:
Rajavithi Hospital
Information provided by:
Rajavithi Hospital
ClinicalTrials.gov Identifier:
NCT00283023
First received: January 25, 2006
Last updated: August 2, 2008
Last verified: August 2008
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Purpose
Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.
| Condition | Intervention | Phase |
|---|---|---|
|
Demyelinating Diseases |
Procedure: Oligodendrocyte progenitor cell culture/craniotomy |
Phase 1 |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label |
| Official Title: | Phase 1: Oligodendrocyte Progenitor Cell Culture From Human Brain |
Further study details as provided by Rajavithi Hospital:
Primary Outcome Measures:
- Number of oligodendrocyte progenitor cell differentiation [ Time Frame: one month ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 100 |
| Study Start Date: | December 2007 |
| Estimated Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: A
Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.
|
Procedure: Oligodendrocyte progenitor cell culture/craniotomy
Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply
Other Name: Rajavithi Oligodendrocyte progenitor cell culture protocol
|
Detailed Description:
Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.
Eligibility| Ages Eligible for Study: | 20 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Male or female 20-65 years of age
- Informed consent
- Has elective craniotomy surgery
Exclusion Criteria:
- HIV, hepatitis, and other central nervous system (CNS) infections
- Dementia, Alzheimer disease, and neurodegenerative disease
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00283023
Contacts
| Contact: Subsai Kongsaengdao, M.D. | +66-6-6596159 | skhongsa@gmail.com |
Locations
| Thailand | |
| Assistant Professor Subsai Kongsaengdao | Recruiting |
| Bangkok, Thailand, 10400 | |
| Contact: Subsai Kongsaengdao, M.D. 66-86-6596159 skhongsa@gmail.com | |
| Contact: Piyathida Boontee, M.D. 66-81-8423854 pboontee@yahoo.com | |
Sponsors and Collaborators
Rajavithi Hospital
Investigators
| Principal Investigator: | Subsai Kongsaengdao, M.D. | Division of Neurology, Department of Medicine, Rajavithi Hospital : Thailand |
More Information
No publications provided
| Responsible Party: | Assistant Professor Subsai Kongsaengdao, Rajavithi Hospital |
| ClinicalTrials.gov Identifier: | NCT00283023 History of Changes |
| Other Study ID Numbers: | RH-CMR-003, RVH-CMR-003 grant |
| Study First Received: | January 25, 2006 |
| Last Updated: | August 2, 2008 |
| Health Authority: | Thailand: Ministry of Public Health |
Keywords provided by Rajavithi Hospital:
|
All selective craniotomy |
Additional relevant MeSH terms:
|
Demyelinating Diseases Nervous System Diseases |
ClinicalTrials.gov processed this record on May 21, 2013