Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study
Recruitment status was Active, not recruiting
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Purpose
The purpose of this study is to examine the role of genetic and environmental factors in the cause of Parkinson's disease.
| Condition |
|---|
|
Parkinson's Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Twins and the Risk of PD: A Clinical and Imaging Study |
- Onset of Parkinson's disease [ Time Frame: duration of the project ] [ Designated as safety issue: No ]
- Age of Parkinson's disease onset [ Time Frame: duration of the project ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 250 |
| Study Start Date: | April 2001 |
| Estimated Study Completion Date: | July 2010 |
| Groups/Cohorts |
|---|
|
1
National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort
|
Detailed Description:
Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous studies in this group indicated that genetic factors were involved only in early-onset PD, however there was no follow-up to these studies.
The purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins—at least one of whom has PD.
The overall goal of this research is determine the contributions of genetic and environmental factors in the cause of PD.
The study will involve traditional clinical research methods, such as a clinical examination, as well as innovative imaging techniques, such as single photon emission computed tomography (SPECT). SPECT—a nuclear imaging test involving blood flow to tissue—is used to evaluate certain brain functions.
Findings from this study may help to set research priorities in PD, and to develop tools for early detection of the disorder.
Eligibility| Ages Eligible for Study: | 77 Years to 88 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Participants will be recruited from a closed cohort—the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort
Inclusion:
- Participants will be recruited from a closed cohort—the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort
Contacts and Locations| United States, California | |
| The Parkinson's Institute, 675 Almanor Avene | |
| Sunnyvale, California, United States, 94085 | |
| Principal Investigator: | Caroline M. Tanner, MD | The Parkinson's Institute |
More Information
No publications provided
| Responsible Party: | Caroline M. Tanner, MD, PhD, Director of Clinical Research, The Parkinson's Institute |
| ClinicalTrials.gov Identifier: | NCT00282802 History of Changes |
| Other Study ID Numbers: | R01NS40467, R01 NS 40467-01 |
| Study First Received: | January 26, 2006 |
| Last Updated: | July 1, 2009 |
| Health Authority: | United States: Federal Government |
Keywords provided by The Parkinson's Institute:
|
Parkinson's Disease twins SPECT |
National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort Registry NAS/NRC World War II Veteran Twins |
Additional relevant MeSH terms:
|
Parkinson Disease Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases |
Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases |
ClinicalTrials.gov processed this record on June 18, 2013