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High-protein and High-carbohydrate Diets' Effect on Urinary Concentrating Ability

This study has been completed.
Sponsor:
Information provided by:
Regional Hospital Holstebro
ClinicalTrials.gov Identifier:
NCT00282321
First received: January 24, 2006
Last updated: February 19, 2010
Last verified: February 2010
History of Changes
  Purpose

We wanted to test urinary concentrating ability and AQP-2 expression in kidney during high-protein and high-carbohydrate diet.


Condition Intervention Phase
Healthy
 Behavioral: High Protein diet
Behavioral: High carbohydrate diet
 Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment

Further study details as provided by Regional Hospital Holstebro:

Primary Outcome Measures:
  • u-AQP-2
  • FeNa+

Estimated Enrollment: 20
Study Start Date: May 2007
Study Completion Date: June 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • (1) Genders; both mal and female
  • (2) Age; 18- 65 years old
  • (3) BMI; below 30
  • (4) Females had to bee in oral contraceptive treatment

Exclusion Criteria:

  • (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs
  • (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose)
  • (3) Albuminuria or glucosuria
  • (4) Cancer
  • (5) Arterial hypertension
  • (6) Alcohol abuse
  • (7) Use of tobacco
  • (8) Medical treatment, except oral contraceptives
  • (9) Pregnancy or breast feeding
  • (10) Medicine abuse
  • (11) Donation of blood less than 1 month before the study.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00282321

Locations
Denmark
Department of Medicine, Holstebro Hospital
Holstebro, Denmark
Sponsors and Collaborators
Regional Hospital Holstebro
Investigators
Study Chair: Erling B Pedersen, Professor Holstebro Hospital, 7500 Holstebro Denmark
Principal Investigator: Thomas G Knudsen, MD Holstebro Hospital, 7500 Holstebro, Denmark
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00282321     History of Changes
Other Study ID Numbers: MED.RES.HOS.2006.01.TGK
Study First Received: January 24, 2006
Last Updated: February 19, 2010
Health Authority: Denmark: Ethics Committee

ClinicalTrials.gov processed this record on May 19, 2013