Prevention of Suicide in Primary Care Elderly: Collaborative Trial (PROSPECT) - Full Text View

Sponsor:	Weill Medical College of Cornell University
Collaborators:	University of Pennsylvania University of Pittsburgh National Institute of Mental Health (NIMH) Forest Laboratories The John A. Hartford Foundation
Information provided by:	Weill Medical College of Cornell University
ClinicalTrials.gov Identifier:	NCT00279682

Purpose

The purpose of this study was to determine the effect of a primary care intervention on reducing suicidal ideation and depression in older patients.

Condition	Intervention	Phase
Depression Suicide, Attempted	Behavioral: treatment guidelines and depression care management	Phase IV

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Prevention
Official Title:	Prevention of Suicide in Primary Care Elderly: Collaborative Trial

Resource links provided by NLM:

MedlinePlus related topics: Depression Suicide

U.S. FDA Resources

Further study details as provided by Weill Medical College of Cornell University:

Primary Outcome Measures:

Hamilton Depression Rating Scale
Scale for Suicide Ideation

Secondary Outcome Measures:

All cause and cause-specific mortality
disability (Sf12; instrumental activities of daily living)

Estimated Enrollment:	1200
Study Start Date:	May 1999
Estimated Study Completion Date:	August 2003

Detailed Description:

Suicide rates are highest in late life; the majority of older adults who die by suicide have seen a primary care physician in preceding months. Depression is the strongest risk factor for late-life suicide and for suicide’s precursor, suicidal ideation.

The aim of the study was to determine the extent to which an intervention taht combined treatment guidelines with care management reduced rates of depression and suicide ideation in older primary care patients. The study randomized 20 primary care practices from New York City, Philadelphia, and Pittsburgh regions into intervention or usual car. The used a two-stage sampling design that resulted in a representative sample with an oversample of depressed patients (total n=1238 subjects including 598 with a depression diagnosis and 640 with no depression diagnosis). Patients were assessed at baseline, 4, 8, 12, 18 and 24 months.

Eligibility

Ages Eligible for Study:	60 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

upcoming appointment with primary care clinician

Exclusion Criteria:

inability to give consent
minimental status examination <18
ability to communicate in English

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00279682

Locations

United States, New York
Weill Medical College of Cornell University
White Plains, New York, United States, 10506
United States, Pennsylvania
Universilty of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213

Sponsors and Collaborators

Weill Medical College of Cornell University

University of Pennsylvania

University of Pittsburgh

National Institute of Mental Health (NIMH)

Forest Laboratories

The John A. Hartford Foundation

Investigators

Principal Investigator:	George S Alexopoulos, MD	Weill Medical College of Cornell University
Principal Investigator:	Ira Katz, MD. Ph.D.	University of Pennsylvania
Principal Investigator:	Charles F Reynolds, MD	University of Pittsburgh

More Information

Publications:

Bruce ML, Ten Have TR, Reynolds CF 3rd, Katz II, Schulberg HC, Mulsant BH, Brown GK, McAvay GJ, Pearson JL, Alexopoulos GS. Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial. JAMA. 2004 Mar 3;291(9):1081-91.

Alexopoulos GS, Katz IR, Bruce ML, Heo M, Ten Have T, Raue P, Bogner HR, Schulberg HC, Mulsant BH, Reynolds CF 3rd; PROSPECT Group. Remission in depressed geriatric primary care patients: a report from the PROSPECT study. Am J Psychiatry. 2005 Apr;162(4):718-24.

Gallo JJ, Bogner HR, Morales KH, Post EP, Ten Have T, Bruce ML. Depression, cardiovascular disease, diabetes, and two-year mortality among older, primary-care patients. Am J Geriatr Psychiatry. 2005 Sep;13(9):748-55.

Bruce ML, Pearson JL. Designing an intervention to prevent suicide: PROSPECT (Prevention of Suicide in Primary Care Elderly: Collaborative Trial), Dialogues in Clinical Neuroscience,1:100-112, 1999.

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Bao Y, Alexopoulos GS, Casalino LP, Ten Have TR, Donohue JM, Post EP, Schackman BR, Bruce ML. Collaborative depression care management and disparities in depression treatment and outcomes. Arch Gen Psychiatry. 2011 Jun;68(6):627-36.

Alexopoulos GS, Reynolds CF 3rd, Bruce ML, Katz IR, Raue PJ, Mulsant BH, Oslin DW, Ten Have T; PROSPECT Group. Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study. Am J Psychiatry. 2009 Aug;166(8):882-90. Epub 2009 Jun 15.

ClinicalTrials.gov Identifier:	NCT00279682 History of Changes
Other Study ID Numbers:	R01MH59366, R01MH59380, R01MH59381
Study First Received:	January 17, 2006
Last Updated:	January 17, 2006
Health Authority:	United States: Food and Drug Administration

Keywords provided by Weill Medical College of Cornell University:

depression
suicide
geriatric
elderly
primary care

Additional relevant MeSH terms:

Depression
Depressive Disorder
Suicide
Suicide, Attempted

Behavioral Symptoms
Mood Disorders
Mental Disorders
Self-Injurious Behavior

ClinicalTrials.gov processed this record on February 09, 2012