Capecitabine Associated With Weekly Paclitaxel in Metastatic Breast Cancer.

Inclusion Criteria:

• Femal patient aged > 18 years
• Histologically proven breast adenocarcinoma
• HER2 negative receptors
• previously received first or second line chemotherapy for metastatic disease
• previously treated with anthracycline and/or docetaxel in adjuvant and/or as first or second line therapy
• presence of one or several evaluable metastatic lesion(s)
• presence of at least one target lesion not previously irradiated
• previously treated with hormonotherapy in adjuvant or in metastatic line (treatment will be ceased upon patient registration in the study)
• ECOG Performance status < 2
• adequate biological values
• patient who has clearly given her consent by signing on informed consent form prior to participation

Exclusion Criteria:

• patient previously treated with paclitaxel or capecitabine for metastatic breast cancer
• patient with only local metastatic disease (with the exception of axillary lymph nodes)
• active symptomatic brain metastasis
• patient with an history of significant cardiovascular impairment (congestive heart failure> NYHA grade II, unstable angina or myocardial infraction within the past six months or serious cardiac arrhythmia)
• peripheric neuropathy grade ≥ 2
• history of another malignancy within past 5 years that could confound diagnosis or staging of breast cancer (with the exception of in situ cacinoma of the cervix or adequately treated basel cell carcinoma of the skin)
• patient with any medical or psychiatric condition that, in the opinion of the Principal Investigator, would preclude her from participating in this study
• patient with a known allergy to one or several of the study compounds
• patients who may not be regularly available due to geographical, social or family reasons
• history of renal, hepatic or metabolic pathology that could preclude with metabolism or elimination of the study product
• deficiencies of the upper intestinal tract, malabsorption syndrome
• patient who is pregnant, breast-feeding or using inadequate contraception