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Benazepril for Advanced Chronic Renal Insufficiency

This study has been terminated.
Sponsor:
Information provided by:
Southern Medical University, China
ClinicalTrials.gov Identifier:
NCT00270426
First received: December 23, 2005
Last updated: May 4, 2006
Last verified: March 1999
History of Changes
  Purpose

The purpose of this study is to further determine whether benazepril, could safely slow the progression of renal dysfunction in non-diabetic patients with advanced renal insufficiency.


Condition Intervention
Chronic Kidney Failure
 Drug: Benazepril

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Southern Medical University, China:

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. serum creatinine concentration 1.5-5.0 mg/dL (133-442 µmol/L)
  2. creatinine clearance 20 to70 mL/min/1.73 m2, with variations of less than 30 percent in the three months before the screening evaluation
  3. non-diabetic renal disease
  4. persistent proteinuria (defined as urinary protein excretion greater than 0.3 g/day for three or more months without evidence of urinary-tract infection or overt heart failure [New York Heart Association class III–IV]).

Exclusion Criteria:

  • immediate need for dialysis; treatment with corticosteroids, non-steroidal anti-inflammatory drugs or immunosuppressive drugs; renovascular disease; myocardial infarction or cerebrovascular accident in the year preceding the trial; connective-tissue disease; obstructive uropathy.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00270426

Sponsors and Collaborators
Southern Medical University, China
Investigators
Principal Investigator: Fan Fan Hou, M.D.,Ph.D. Southern Medical University
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00270426     History of Changes
Other Study ID Numbers: SouthernMUC
Study First Received: December 23, 2005
Last Updated: May 4, 2006
Health Authority: China: Food and Drug Administration

Keywords provided by Southern Medical University, China:
Advanced Chronic Renal Insufficiency
Benazepril

Additional relevant MeSH terms:
Kidney Failure, Chronic
Renal Insufficiency, Chronic
Renal Insufficiency
Kidney Diseases
Urologic Diseases
Benazepril
Angiotensin-Converting Enzyme Inhibitors
 Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Antihypertensive Agents
Cardiovascular Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on May 23, 2013