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Benazepril for Advanced Chronic Renal Insufficiency

This study has been terminated.
Sponsor:
Information provided by:
Southern Medical University, China
ClinicalTrials.gov Identifier:
NCT00270426
First received: December 23, 2005
Last updated: May 4, 2006
Last verified: March 1999
  Purpose

The purpose of this study is to further determine whether benazepril, could safely slow the progression of renal dysfunction in non-diabetic patients with advanced renal insufficiency.


Condition Intervention
Chronic Kidney Failure
Drug: Benazepril

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Southern Medical University, China:

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. serum creatinine concentration 1.5-5.0 mg/dL (133-442 µmol/L)
  2. creatinine clearance 20 to70 mL/min/1.73 m2, with variations of less than 30 percent in the three months before the screening evaluation
  3. non-diabetic renal disease
  4. persistent proteinuria (defined as urinary protein excretion greater than 0.3 g/day for three or more months without evidence of urinary-tract infection or overt heart failure [New York Heart Association class III–IV]).

Exclusion Criteria:

  • immediate need for dialysis; treatment with corticosteroids, non-steroidal anti-inflammatory drugs or immunosuppressive drugs; renovascular disease; myocardial infarction or cerebrovascular accident in the year preceding the trial; connective-tissue disease; obstructive uropathy.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00270426

Sponsors and Collaborators
Southern Medical University, China
Investigators
Principal Investigator: Fan Fan Hou, M.D.,Ph.D. Southern Medical University
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00270426     History of Changes
Other Study ID Numbers: SouthernMUC
Study First Received: December 23, 2005
Last Updated: May 4, 2006
Health Authority: China: Food and Drug Administration

Keywords provided by Southern Medical University, China:
Advanced Chronic Renal Insufficiency
Benazepril

Additional relevant MeSH terms:
Kidney Failure, Chronic
Renal Insufficiency
Renal Insufficiency, Chronic
Kidney Diseases
Urologic Diseases
Benazepril
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Cardiovascular Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protease Inhibitors
Therapeutic Uses

ClinicalTrials.gov processed this record on November 25, 2014