Intraarticular Analgesia After Total Knee Arthroplasty, a Randomised Study
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The study aims to compare two different kinds of pain treatment after total knee replacement (operation with artificial knee joint): 1) a large local injection in and around the knee, supplemented with injection the day after, or 2) the department's conventional pain treatment consisting of continuous nerve block in the groin.
| Condition | Intervention |
|---|---|
|
Arthroplasty, Replacement, Knee |
Procedure: femoral nerve block Procedure: knee infiltration and injection via catheter |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Postoperative Analgesia After Total Knee Arthroplasty. A Comparison of Continuous Femoral Block and Extensive Intraoperative Infiltration With Local Anesthetic Supplemented With Intraarticular Bolus the Following Day. |
- pain, by numeric rating scale
- pain, by consumption of analgesics
- side effects
- return of function
| Estimated Enrollment: | 80 |
| Study Start Date: | February 2005 |
| Estimated Study Completion Date: | March 2006 |
Postoperative pain after total knee arthroplasty is moderate to severe and can be difficult to treat. The current use of femoral nerve block by ropivacain pump for 48 hours provides considerable analgesia, but patients often experience slight motor block, inhibiting rehabilitation, and pain in the posterior part of the knee, innervated by the sciatic nerve. This study compares femoral nerve block to a new technique, where ropivacaine, ketorolac and adrenalin is used to infiltrate the tissue in and around the knee joint during surgery, and is injected by an intraarticular catheter at 10 pm on the day of surgery and again at 10 am the day after. Data of pain scores, analgesia consumption, adverse effects and mobilisation is collected for the first four postoperative days.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- patients planned for primary total knee arthroplasty due to primary arthrosis
Exclusion Criteria:
- Patients unable to provide informed consent
- patients with contraindications for spinal anesthesia
- patients with known hypersensitivity towards the used drugs
- patients with severe chronic neurogenic pain or sensitivity disorders in the leg to be operated
- patients who have undergone major bone surgery in the knee to be operated
Contacts and Locations| Denmark | |
| Aarhus Hospital, Tage Hansens Gade | |
| Aarhus, Denmark, DK-8000 | |
| Principal Investigator: | Else Tønnesen, Professor | Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark |
| Principal Investigator: | Kjeld Søballe, Professor | Orthopedic Center, Aarhus University Hospital, Aarhus, Denmark |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00269529 History of Changes |
| Other Study ID Numbers: | 20050003 |
| Study First Received: | December 22, 2005 |
| Last Updated: | October 12, 2006 |
| Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
Keywords provided by University of Aarhus:
|
postoperative pain knee arthroplasty analgesia infiltration femoral nerve block |
ClinicalTrials.gov processed this record on June 18, 2013