Brain Aging Project--Kansas University

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2009 by National Institute on Aging (NIA).
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
University of Kansas
Information provided by:
National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:
NCT00267124
First received: December 16, 2005
Last updated: April 28, 2009
Last verified: April 2009
  Purpose

The purpose of this study is to determine the effects of exercise and cardiorespiratory fitness on age-related brain changes.


Condition
Alzheimer's Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: KU Brain Aging Project

Resource links provided by NLM:


Further study details as provided by National Institute on Aging (NIA):

Biospecimen Retention:   Samples With DNA

Blood samples are collected analyzed and banked as whole blood, serum, white blood cells


Estimated Enrollment: 120
Study Start Date: November 2004
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
elderly people who have normal cognition
2
elderly people who have mild to moderate Alzheimer's disease

Detailed Description:

The mission of the KU Brain Aging Project is to promote healthy brain aging. How the brain changes with age is not well-characterized and even less is known about the factors influencing the rate of brain aging. Thus, we are using MRI scans to examine the structure of the brain in relation to important lifestyle factors. This will allow us to better understand the processes influencing the brain as it ages. In turn, this will help identify specific ways to promote healthy brain aging and, perhaps, prevent the onset of Alzheimer's disease.

Participants complete 4 visits over several months. The first visit entails a clinical evaluation and memory testing involving the use of paper and pencil testing. The second visit is an MRI brain scan which lasts approximately one hour. The third visit involves drawing blood for laboratory testing and blood banking for future lab studies, lasting roughly 4 hours. The glucose tolerance test is administered. The fourth and final visit is an assessment of the participant's metabolism and exercise testing. This visit lasts approximately two hours.

  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

KU memory clinic patients, volunteers from the community, and the states of Kansas and Missouri

Criteria

Inclusion Criteria:

  • Age 65 years or older
  • Healthy male or female
  • Normal control volunteers and early Alzheimer's disease patients
  • Clinical Dementia Rating of 0, 0.5, or 1.0
  • On stable doses of medications

Exclusion Criteria:

  • Unstable angina
  • Schizophrenia
  • Clinical signs of depression; major depression; mental health disorder; nervous system disorder
  • Significant visual/auditory impairment
  • Significant system illness; cancer
  • Pacemaker/metal
  • Thyroid problems
  • Kidney dialysis
  • Organ transplant
  • Alcoholism
  • Heart surgery
  • Insulin
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00267124

Locations
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Sponsors and Collaborators
University of Kansas
Investigators
Principal Investigator: Jeffrey Burns, MD University of Kansas Medical Center, Landon Center on Aging
  More Information

Additional Information:
No publications provided

Responsible Party: Jeffrey Burns, MD, University of Kansas Medical Center
ClinicalTrials.gov Identifier: NCT00267124     History of Changes
Other Study ID Numbers: IA0089, 1R03AG026374-01
Study First Received: December 16, 2005
Last Updated: April 28, 2009
Health Authority: United States: Federal Government

Keywords provided by National Institute on Aging (NIA):
cognitive decline
dementia
neuroimaging

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on April 17, 2014