A Study of the Efficacy and Safety of Topiramate Treatment in Patients With Epilepsy

This study has been completed.
Sponsor:
Information provided by:
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
ClinicalTrials.gov Identifier:
NCT00266591
First received: December 16, 2005
Last updated: June 6, 2011
Last verified: January 2011
  Purpose

The purpose of this study is to evaluate the effectiveness and safety of topiramate (an antiepileptic medication) in patients with epilepsy.


Condition Intervention Phase
Epilepsy
Seizures
Drug: topiramate
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Single Center TOPAMAX� (Topiramate) Monotherapy Trial in Subjects With Refractory Partial Onset Seizures

Resource links provided by NLM:


Further study details as provided by Johnson & Johnson Pharmaceutical Research & Development, L.L.C.:

Primary Outcome Measures:
  • Time to patient exit (withdrawal) from the double-blind phase of the study, based on 4 pre-established exit criteria corresponding to therapeutic failure.

Secondary Outcome Measures:
  • Investigator and patient global evaluation of the clinical response; safety evaluations conducted throughout the study (incidence and severity of adverse events, changes in physical and neurological examinations, laboratory tests)

Enrollment: 51
Study Start Date: October 1992
Study Completion Date: April 1997
Detailed Description:

Epilepsy is a disease characterized by seizures, which are abnormal electrical discharges in the brain that temporarily disrupt normal brain function. Seizures are classified as "generalized," originating in both sides of the brain at the same time, or "partial onset," starting in one area of the brain. Antiepileptic medications, such as topiramate, are selected based on a patient's seizure type. The specific type of seizure is not always obvious at the time of diagnosis. This is a randomized, double-blind, parallel-group study to evaluate the effectiveness and safety of two doses of topiramate (100 or 1000 mg per day) in patients with partial onset seizures. The study is composed of three phases: an 8-week baseline phase during which patients take their standard antiepileptic drugs, a 1-week open-treatment phase during which patients continue standard antiepileptic drugs and add on topiramate (100 mg/day), and a double-blind treatment phase. The double-blind phase is divided into two periods: a 5-week conversion period and an 11-week treatment period with topiramate. In the conversion period, patients gradually discontinue their baseline antiepileptic drugs. Those assigned to the topiramate 1000 mg/day group start by taking the 100 mg/day dose and gradually increase to 1000 mg/day (or to their maximum tolerated dose) over a 5-week period. Patients assigned to topiramate 100 mg/day receive one 100 mg tablet (plus placebo tablets to maintain the blind during the 5 week period). Patients in both groups continue with their dose for the 11-week treatment period. Patients are provided with diaries to record information regarding any seizures occurring during the study. The primary assessment of effectiveness is the amount of time the patient receives topiramate in the double-blind treatment phase before exiting (withdrawing) from the study. Four exit criteria for withdrawal are designed to correspond to therapeutic failure and to ensure subject safety: i) a doubling of the average monthly (28-day) seizure frequency compared to baseline; ii) a doubling of the highest two-day seizure frequency that occurred during baseline; iii) a single generalized seizure if none occurred during the baseline phase; iv) or prolongation of generalized seizure duration (serial seizures or status epilepticus) as compared to the baseline phase seizure duration and requiring intervention. Safety assessments during the study include the frequency and severity of adverse events, results of clinical laboratory tests (hematology, biochemistry, and urinalysis), blood gastrin levels, measurements of vital signs and body weight, patient global evaluations of study drug tolerability, neurologic examinations, neuropsychologic tests, and physical examination findings. Based on the investigator's judgment, all patients completing the study could be enrolled into an open-label extension phase, during which patients know the identity and dose of topiramate. The study hypothesis is that the 1000 mg/day dose of topiramate is superior to the 100 mg/day dose in the amount of time before patients exit (withdraw based on pre-established exit criteria corresponding to therapeutic failure) from the double-blind phase. 100 mg/day group: one Topiramate 100 mg oral tablet (plus placebo tablets to maintain the blind) for 16 weeks. 1000 mg/day group: starting with one Topiramate 100 mg oral tablet and gradually increasing to 1000 mg/day (or maximum tolerated dose) over 5 weeks, and continuing that dose for 11 weeks.

  Eligibility

Ages Eligible for Study:   14 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Body weight >90 pounds
  • documented history of frequent partial onset seizures
  • at least four partial onset seizures per month while taking a constant antiepileptic drug dosage during the screening period
  • a recent history of maintenance on 1 or 2 standard antiepileptic drugs
  • females must be postmenopausal for at least 1 year, or if of childbearing age, be sexually abstinent, surgically sterile, or using adequate birth control measures, and have a negative pregnancy test before study entry.

Exclusion Criteria:

  • Patients who do not have epilepsy, such as patients with treatable causes of seizure (for example, cancer or active infection)
  • have a documented history (previous 3 months) of generalized status epilepticus while receiving anticonvulsant medication (status epilepticus is a prolonged seizure or seizures repeated frequently over 20 to 30 minutes so that recovery between episodes does not occur)
  • have seizures occurring in only clustered patterns (numerous seizures over a short period of time)
  • a significant history (within 2 years) of medical disease (heart, kidney, hormone, gynecologic, muscle, bone, gastrointestinal, metabolic, liver diseases or cancer with a metastatic potential)
  • history of alcohol or drug abuse history within the past 1 year.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00266591

Sponsors and Collaborators
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Investigators
Study Director: Johnson & Johnson Pharmaceutical Research & Development, L.L. C. Clinical Trial Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00266591     History of Changes
Other Study ID Numbers: CR005470
Study First Received: December 16, 2005
Last Updated: June 6, 2011
Health Authority: United States: Food and Drug Administration

Keywords provided by Johnson & Johnson Pharmaceutical Research & Development, L.L.C.:
Epilepsy
Seizures
Topiramate
Prophylaxis
Antiepileptic
Epileptic seizures
Partial seizure disorder
Brain disease

Additional relevant MeSH terms:
Epilepsy
Seizures
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Topiramate
Anti-Obesity Agents
Anticonvulsants
Central Nervous System Agents
Neuroprotective Agents
Pharmacologic Actions
Physiological Effects of Drugs
Protective Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on October 21, 2014