The Impact of Renin-Angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study
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Purpose
The purpose of this study is to evaluate the cerebral blood flow in subjects with high and low activity in the renin-angiotensin system (RAS).The renin-angiotensin system is a hormone system which is involved in the regulation of the blood pressure. Earlier studies have shown that high RAS activity is associated with a more pronounced cognitive impairment during hypoglycaemia compared to low RAS activity in both type 1 diabetic patients and healthy volunteers. We intend to examine brain activity by oxygen-15 labelled water-PET scanning during hypoglycaemia in response to cognitive function testing in 20 healthy male volunteers with high and low RAS activity, respectively
| Condition | Intervention |
|---|---|
|
Hypoglycemia Cognitive Impairment |
Drug: insulin |
| Study Type: | Observational |
| Study Design: | Additional Descriptors: Convenience Sample Time Perspective: Cross-Sectional Time Perspective: Prospective |
| Official Title: | The Impact of Renin-Angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study |
| Estimated Enrollment: | 20 |
| Study Start Date: | January 2006 |
| Estimated Study Completion Date: | December 2006 |
The purpose of this study is to evaluate the regional cerebral blood flow in subjects with high and low activity in the renin-angiotensin system (RAS). Earlier studies have shown that high RAS activity is associated with a more pronounced cognitive impairment during hypoglycaemia compared to low RAS activity in both type 1 diabetic patients and healthy volunteers. We intend to examine brain activity by oxygen-15 labelled water-PET scanning during hypoglycaemia in response to cognitive function testing in 20 healthy male volunteers with high and low RAS activity, respectively.
Eligibility| Ages Eligible for Study: | 18 Years to 40 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:Male Age 18-40 years Right-handed In good general health based on history High/low RAS activity (high ACE activity, A-allele for angiotensin II receptor (subtype 2) and high plasma angiotensinogen, or low ACE activity, low plasma angiotensinogen and not carrier of the A-allele for angiotensin II receptor (subtype 2)).
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Exclusion Criteria:
Any evidence of mental, neurological or medical illnesses. The presence of ferromagnetic metal in the body. Claustrophobia Exposure to radiation within the last year
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Contacts and Locations| Denmark | |
| Medical Department I, Hillerød Hospital | |
| Hillerød, Denmark, 3400 | |
| Study Chair: | Birger Thorsteinsson, MD, DMSci | Hypoglycaemia Research Group |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00264641 History of Changes |
| Other Study ID Numbers: | 2005-2-15 |
| Study First Received: | December 12, 2005 |
| Last Updated: | March 27, 2006 |
| Health Authority: | Denmark: The Regional Committee on Biomedical Research Ethics |
Keywords provided by Hypoglycaemia Research Group:
|
Hypoglycemia Cognitive impairment PET CalCAP |
Additional relevant MeSH terms:
|
Hypoglycemia Cognition Disorders Glucose Metabolism Disorders |
Metabolic Diseases Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders |
ClinicalTrials.gov processed this record on May 16, 2013