Neural Changes in the Aging Auditory System
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.
Auditory Perceptual Disorders
Drug: Hormone Replacement Therapy - HRT
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Age-Related Hearing Loss: Presbycusis & Its Neural Bases|
|Study Start Date:||January 2001|
|Estimated Study Completion Date:||February 2005|
Background: Female hormone influences on the development and aging of the auditory system are not completely understood. The present study retrospectively analyzed and compared hearing abilities among post-menopausal women taking hormone replacement therapy (HRT), treated with estrogen and progesterone (E+P); estrogen alone (E), and a third (control - NHRT) group, matched for age, who did not receive any HRT.
Methods: 126 subjects, (60-86 yr), N=32, E+P; N=31, E; N= 63, NHRT; matched for age and health status participated. All had relatively healthy medical histories, absence of significant noise exposure, middle ear problems, major surgeries or current/heavy smoking. Hearing tests included pure tone audiometry (PTA), tympanometry, distortion-product otoacoustic emissions (DPOAEs), transient otoacoustic emissions (TEOAEs) and hearing-in-noise-test (HINT). The latter is a test for speech perception in background noise: the major complaint of hearing-impaired persons.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00264407
|United States, New York|
|International Center Hearing & Speech Research - NTID - RIT|
|Rochester, New York, United States, 14623-5604|
|University of Rochester Medical Center|
|Rochester, New York, United States, 14642|
|Study Director:||Robert D Frisina, Ph.D.||University of Rochester Medical School|