Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections

This study has been completed.

Study NCT00261807 Information provided by University of Maryland

First Received: December 1, 2005 Last Updated: May 30, 2008 History of Changes

No Study Results Posted on ClinicalTrials.gov for this Study

About Study Results Reporting on ClinicalTrials.gov

Study Status:	This study has been completed.
Study Completion Date:	May 2008
Primary Completion Date:	May 2008 (Final data collection date for primary outcome measure)

Publications:

References 1. Wang K, Shin C. Necrotizing fasciitis of the extremities. J Trauma 1992; 32:19-182. 2. Swartz MN. Cellulitis and subcutaneous tissue infections. In Mandell AL, Dolin R, Bennett JE (eds). Principles and Practice of Infectious Diseases. New York, Churchill Livingstone, 1995, p 909-929. 3. Stone HH, Martin JD. Synergistic necrotizing cellulitis. Ann. Surg. 1972; 175: 702-710. 4. Stevens DL, Tanner MH, Winship J, et al. Severe group A streptococcal infections associated with a toxic shock-like syndrome and a scarlet fever toxin. N Engl J Med 1989; 1: 321. 5. Elliott DC, Kufera JA, Myers RAM. Necrotizing soft tissue infections; risk factors for mortality and strategies for management. Ann. Surg 1966; 224: 672-683. 6. Asfar SK. Necrotizing fasciitis. Br. J. Surg. 1991; 7-8, 828-840. 7. Rotstein OD, Pruett TL, Simmons RL. Mechanisms of microbial synergy in polymicrobial surgical infections. Rev Infect Dis. 1985; 7: 151-170. 8. Naimi, TS, LeDell RH, Como-Sabelth K, et al. Comparison of community-and health care associated MRSA infection. JAMA 2003; 290: 2976. 9. Herold, BC, Immerglick LC, Maranana MC, et al. Community-acquired methicillin-resistant S. aureus in children with no identified predisposing risk. JAMA 1998; 279: 593. 10. Arbeit RD, Maki D, Tally FP, Campanaro E, Eisenstein BI. Daptomycin 98-01 and 99-01 Investigators. The safety and efficacy of daptomycin for the treatment of complicated skin skin-structure infection.. Clin. Infect. Dis. 2004 June 15: 38 (12): 1673-81, Epub 2004 May 11. Ellie J.C.Goldstein, Diane M.Citron, C.Vreni Merriam, et al. In Vitro Activities of daptomycin, Vancomycin, Quinupristin-Dalfopristin, Linezolid, and Five Other Antimicrobials against 307 Gram-Positive Anaerobic and 31 Corynebacterium Clinical Isolates. Antimicrobial agents and chemoterapy,2003 June: 47(1) 337-341 12. Barry H.Dvorchik, PhD, FCP, and David Damphousse,MS. Pharmacokinetics of daptomycin in Moderately Obese, Morbidly obese, and Matched Nonobese Subjects.J Clin Pharmacol 2005; 45:48-56 13. Package insert for CUBICIN (daptomycin for injection)