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Food Rheology and Feeding in Lean and Obese Humans

This study has been completed.
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by:
Purdue University
ClinicalTrials.gov Identifier:
NCT00260130
First received: November 29, 2005
Last updated: February 11, 2011
Last verified: February 2011
History of Changes
  Purpose

The 2010 National Health Objectives call for a reduction in the prevalence of obesity. The marked recent increase in overweight and obesity prevalence implicates behavioral factors in the etiology of the epidemic. The present proposal hypothesizes the trend is attributal, in part, to increasing consumption of energy-yeilding beverages since they are a significant and increasing source of dietarty energy and they elicit weaker appetitive and dietary responses than solid foods.


Condition Intervention
Obesity
Overweight
Diabetes
 Other: food in fluid form
Other: food in solid form

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Official Title: Study 1: Viscosity Study Study 2: Meal Timing Study Study 3:Chronic Fluid and Solid Food Intake in Lean and Overweight Individuals

Resource links provided by NLM:

MedlinePlus related topics: Diabetes Obesity
U.S. FDA Resources

Further study details as provided by Purdue University:

Primary Outcome Measures:
  • satiation and satiety on liquid verses solid foods with concurrent measurements of appetite, dietary intake, energy expenditure and body weight/composition. [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • cephalic phase testing at week 8 [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]

Estimated Enrollment: 34
Study Start Date: February 2005
Study Completion Date: July 2009
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Consuming fruit and vegetable juice
 Other: food in fluid form
dietary intake of fluid forms of vegetables
Active Comparator: 2
Consuming whole fruits and vegetables
 Other: food in solid form
dietary intake of solid forms of vegetables

Detailed Description:

Three human studies are propsed to more fully characterized attributes of liquids and solids that may account for the differential appetitive responses they elicit, potential contributory mechanisms as well as the dietary implications of their consumption. Study 1 will contrast the acute effects of fluid and solid foods varying in macronutrient content on satiation, satiety and feeding. Study 2 will determine if the pattern of fluid and solid ingestion influences satiety and feeding by monitoring appetitive and dietary responses to energy and macronutrient matched fluid and solid loads ingested as meal components or between meal snacks. To better assess the clinical implications ofdiets incorpprating liquid or solid supplements. Study 3 will entail chronic ingestion of matched energy yeilding fluid or solid loads with concurrent measurement of appetite, dietary intake, energy expenditureand body weight/composition.

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI 18-23 or 27-35
  • weight stable
  • constant habitual activity pattern
  • low fruit/vegetable consumer
  • non-restrained eater

Exclusion Criteria:

  • diabetic
  • taking medication known to influence appetite
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00260130

Locations
United States, Indiana
Purdue University
West Lafayette, Indiana, United States, 47906
Sponsors and Collaborators
Purdue University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Principal Investigator: Richard D Mattes, MPH, PhD, RD Purdue University
  More Information

Additional Information:
Dr. Mattes Laboratory for Sensory and Ingestive Studies web site.  This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party: Richard Mattes MPH, Ph.D., R.D, Purdue University
ClinicalTrials.gov Identifier: NCT00260130     History of Changes
Other Study ID Numbers: DK63185 (completed), R01DK063185, Study 1: 503001275, Study 2: 508002908, Study 3: 505002589
Study First Received: November 29, 2005
Last Updated: February 11, 2011
Health Authority: United States: Federal Government

Keywords provided by Purdue University:
obesity
food intake
human
energy balance
beverage

Additional relevant MeSH terms:
Obesity
Overweight
Overnutrition
 Nutrition Disorders
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on May 16, 2013