Analysis of Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium
Painful bladder syndrome (PBS)/interstitial cystitis (IC) may be due to the actions of nitric oxide (NO) in the bladder tissue. NO is a gaseous substance with a very short half-life, synthesized by a group of NO-synthase-enzymes in many tissues.
The goal of this study is to illuminate bladder tissue production of NO in individuals with PBS and healthy individuals, by quantification of NO and NO-enzyme expression by different molecular biological methods.
Procedure: Tissue examination for protein- and mRNA-expression of NO
|Study Design:||Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective/Prospective
|Official Title:||A Quantitative Analysis of Protein- and mRNA-Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium|
|Copenhagen University Hospital at Herlev|
|Herlev, Denmark, DK- 2730|
|Study Director:||Pierre Bouchelouche, MD||Roskilde County University Hospital at Koege, Dept. of Clinical Biochemistry|