Text Size

Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) )
ClinicalTrials.gov Identifier:
NCT00251615
First received: November 8, 2005
Last updated: August 3, 2012
Last verified: August 2012
History of Changes
  Purpose

The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium channels present in the vessels being operated on, and the genes that may alter blood vessel function. Possible variation in these genes may change the kind of calcium channels present in blood vessels.


Condition
Atherosclerosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Biospecimen Retention:   Samples With DNA

Vascular tissue obtained from the surgical site that would have otherwise been discarded and Blood Serum


Enrollment: 18
Study Start Date: August 2012
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Detailed Description:

The goal of this study is to learn more about how blood vessels function and the mechanism that causes them to contract. The study will investigate the natural history of diseased blood vessel tissue and the calcium channels in the muscle part of the blood vessel. The study will also examine how genetics influences cardiovascular disease and its causes and treatments.

Patients scheduled for vascular surgery will be approached to participate in this study. During surgery, tissue fragments of diseased and marginal tissue will be obtained. A blood sample will be obtained at either the time of surgery or consent and genomic DNA will be extracted.

  Eligibility

Ages Eligible for Study:   21 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients scheduled for vascular surgery

Criteria

Inclusion Criteria:

  • Ages 21 and older
  • Scheduled for vascular surgery

Exclusion Criteria:

  • Unwillingness to be subjected to diagnostic and/or therapeutic procedures that are deemed not necessary for clinical management
  • Volunteers deemed too fragile to participate in the study by the principal investigator (PI) or the attending physician
  • Inability to obtain informed consent from either the volunteer or the responsible party (durable power of attorney [DPA]) for the volunteer, with the volunteer's assent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00251615

Locations
United States, Maryland
National Institute on Aging, Harbor Hospital
Baltimore, Maryland, United States, 21225
Sponsors and Collaborators
National Institute on Aging (NIA)
Investigators
Principal Investigator: Samer Najjar, MD National Institute on Aging (NIA)
  More Information

Publications:

Responsible Party: National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) )
ClinicalTrials.gov Identifier: NCT00251615     History of Changes
Other Study ID Numbers: AG0058
Study First Received: November 8, 2005
Last Updated: August 3, 2012
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
vascular surgery
vascular aging
arterial aging
surgical tissue
Aging

Additional relevant MeSH terms:
Atherosclerosis
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on May 22, 2013