17-Dimethylaminoethylamino-17-Demethoxygeldanamycin (17-DMAG) in Treating Patients With Metastatic Solid Tumors or Tumors That Cannot Be Removed By Surgery

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2008 by National Cancer Institute (NCI).
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00248521
First received: November 3, 2005
Last updated: August 1, 2013
Last verified: March 2008
  Purpose

RATIONALE: Drugs used in chemotherapy, such as 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

PURPOSE: This phase I trial is studying the side effects and best dose of 17-DMAG in treating patients with metastatic solid tumors or tumors that cannot be removed by surgery.


Condition Intervention Phase
Unspecified Adult Solid Tumor, Protocol Specific
Drug: alvespimycin hydrochloride
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Cancer Research UK Phase I Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of 17-Dimethylaminoethyl-amino-17-Demethoxygeldanamycin (17-DMAG) Given as a Once Weekly Infusion in Patients With Advanced Solid Tumors

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Recommended phase II dose of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) at 28 days after treatment [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Heat shock protein 90 (HSP90) client protein and co-chaperone changes up to 29 days after treatment [ Designated as safety issue: No ]
  • Tumor response by RECIST criteria every 6 weeks while on study [ Designated as safety issue: No ]
  • Clinical pharmacokinetic profile established during the first course of treatment [ Designated as safety issue: No ]

Estimated Enrollment: 35
Study Start Date: October 2005
Estimated Primary Completion Date: January 2007 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

Primary

  • Determine the maximum tolerated dose, dose-limiting toxicity, and recommended phase II dose of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in patients with unresectable or metastatic solid tumors.
  • Determine the feasibility, safety, and toxicity profile of this drug in these patients.

Secondary

  • Determine the clinical pharmacokinetic profile of this drug in these patients.
  • Determine tumor response in patients treated with this drug.
  • Determine the biologically effective dose.

OUTLINE: This is an open-label, non-randomized, dose-escalation, multicenter study.

Patients receive 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) IV over 1 hour on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of 17-DMAG until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. An additional 10 patients are treated at the MTD.

After completion of study treatment, patients are followed for 28 days.

PROJECTED ACCRUAL: Approximately 25-35 patients will be accrued for this study within 12-18 months.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed solid tumor

    • Unresectable or metastatic disease
  • Standard curative or palliative measures do not exist OR are no longer effective OR patient refused such measures
  • No known brain metastases

PATIENT CHARACTERISTICS:

Age

  • 18 and over

Performance status

  • ECOG 0-1

Life expectancy

  • More than 12 weeks

Hematopoietic

  • Absolute neutrophil count > 1,500/mm^3
  • Platelet count ≥ 100,000/mm^3
  • Hemoglobin ≥ 9.0 g/dL

Hepatic

  • Bilirubin normal
  • ALT and AST ≤ 1.5 times upper limit of normal
  • No chronic liver disease
  • Hepatitis B or C negative

Renal

  • Creatinine normal OR
  • Creatinine clearance normal

Cardiovascular

  • No symptomatic New York Heart Association class III-IV cardiac disease
  • No myocardial infarction within the past year
  • No active ischemic heart disease within the past year
  • No poorly controlled angina
  • No uncontrolled dysrhythmia or dysrhythmias requiring antiarrhythmic drugs
  • No transient ischemic attack
  • No stroke
  • No peripheral vascular disease
  • No congenital long QT syndrome
  • No history of serious ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation ≥ 3 beats in a row)
  • QTc < 450 msec (for men) and 470 msec (for woman)
  • LVEF > 40% by MUGA
  • No left bundle branch block

Pulmonary

  • No symptomatic pulmonary disease requiring medication, including any of the following:

    • Dyspnea with or without exertion
    • Paroxysmal nocturnal dyspnea
    • Oxygen requirement
    • Significant pulmonary disease (e.g., chronic obstructive/restrictive pulmonary disease

Other

  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception 4 weeks before, during, and for 6 months after completion of study treatment
  • No known HIV positivity
  • No other malignancy within the past 5 years except adequately treated cone biopsied carcinoma in situ of the cervix or basal cell or squamous cell skin cancer
  • No ongoing or active infection
  • No diabetes mellitus (with evidence of severe peripheral vascular disease or ulcers)
  • No psychiatric illness or social situation that would preclude study compliance
  • No other uncontrolled illness

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • More than 4 weeks since prior immunotherapy
  • Concurrent epoetin alfa allowed

Chemotherapy

  • More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
  • No prior 17-N-allylamino-17-demethoxygeldanamycin (17-AAG)

Endocrine therapy

  • More than 4 weeks since prior endocrine therapy
  • Concurrent luteinizing hormone-releasing hormone analogues for androgen-insensitive prostate cancer and rising prostate-specific antigen allowed

Radiotherapy

  • More than 4 weeks since prior radiotherapy (except for palliative treatment)
  • No prior irradiation field that potentially included the heart (e.g., mantle)

Surgery

  • Not specified

Other

  • Recovered from all prior therapy
  • Concurrent bisphosphonates allowed
  • At least 5 half-lives since prior and no concurrent medication that prolong QTc
  • No other concurrent anticancer or investigational agents
  • No concurrent grapefruit juice
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00248521

Locations
United Kingdom
Institute of Cancer Research - Sutton
Sutton, England, United Kingdom, SM2 5NG
Royal Marsden - Surrey
Sutton, England, United Kingdom, SM2 5PT
Belfast City Hospital Trust Incorporating Belvoir Park Hospital
Belfast, Northern Ireland, United Kingdom, BT8 8JR
Sponsors and Collaborators
Institute of Cancer Research, United Kingdom
Investigators
Study Chair: Ian R. Judson, MA, MD, FRCP Institute of Cancer Research, United Kingdom
  More Information

Publications:
Pacey SC, Wilson RH, Walton M, et al.: A phase I trial of the heat shock protein 90 (HSP90) inhibitor alvespimycin (17-dimethylaminoethylamino-17-demethoxygeldanamycin 17-DMAG) administered weekly, intravenously, to patients with advanced solid tumors. [Abstract] American Association for Cancer Research: Molecular Targets and Cancer Therapeutics, October 22-26, 2007, San Francisco, CA A-PR-6, 2007.

ClinicalTrials.gov Identifier: NCT00248521     History of Changes
Other Study ID Numbers: ICR-PH1/102, CDR0000442402, NCI-6547
Study First Received: November 3, 2005
Last Updated: August 1, 2013
Health Authority: United States: Federal Government

Keywords provided by National Cancer Institute (NCI):
unspecified adult solid tumor, protocol specific

Additional relevant MeSH terms:
Neoplasms

ClinicalTrials.gov processed this record on April 14, 2014