Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse

This study has been completed.
Sponsor:
Information provided by:
New River Pharmaceuticals
ClinicalTrials.gov Identifier:
NCT00248092
First received: November 1, 2005
Last updated: November 1, 2007
Last verified: November 2007
  Purpose

This research is being done to evaluate if NRP104 is a safe drug. The other purpose is to learn if NRP104 produces a high and any other effects like amphetamine and other stimulant drugs that are abused. This information will give some indication if NRP104 can be abused. NRP104 is an investigational drug. This means that it has not been approved by the U.S. Food and Drug Administration (FDA). Healthy people, between the ages of 18 and 55 with histories of substance abuse that include stimulant drugs, may join. Amphetamines are drugs that are used most often to treat attention deficit hyperactivity disorder (ADHD) in children, to treat narcolepsy (excessive sleepiness) and for weight loss.


Condition Intervention Phase
Attention Deficit Disorder With Hyperactivity
Amphetamine-Related Disorders
Substance-Related Disorders
Drug: NRP104
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: A Double-Blind, Randomized, Placebo and Active-Controlled, Six-Period Crossover Study to Evaluate the Likeability, Safety, and Abuse Liability of NRP104 in Healthy Adult Volunteers With Histories of Stimulant Abuse

Resource links provided by NLM:


Further study details as provided by New River Pharmaceuticals:

Primary Outcome Measures:
  • The difference in the time to maximum change from baseline in the Liking scale score (Question 2) from the Drug Rating Questionnaire - Subject (DRQS).

Secondary Outcome Measures:
  • Maximum Liking score (Question 2 from DRQS) change from baseline
  • Question 1 and 3 from the DRQS
  • Question 1, 2 and 3 from the Drug Rating Questionnaire- Observer (DRQO)
  • Subscale of the ARCI (MBG, Amphetamine, BG, LSD and PCAG) (subject)
  • Street Value assessment Questionnaire (subject)
  • Treatment Enjoyment assessment Questionnaire (TEAQ) (subject)
  • Safety
  • Adverse events, laboratory tests, physical examination, vital signs and ECG will be collected to
  • assess the safety and tolerability of NRP104.

Estimated Enrollment: 36
Study Start Date: January 2006
Study Completion Date: May 2006
Detailed Description:

There is a need for a less abusable stimulant medication that can provide symptom control for children with ADHD as compared to the conventional stimulant products.

Currently, the top line amphetamine product Adderall XR(R) for the treatment of children with ADHD involves a once-a-day morning dosing of up to 30 mg per day per Adderall XR(R) Package Insert. Adderall XR(R) has potential for abuse and is hence is classified as a schedule II product.

As part of the development of NRP104 for treatment of children with ADHD, it is important to evaluate the abuse potential of NRP104 in comparison to immediate release d-amphetamine. A previous exploratory dose ranging study (NRP104.A01) with NRP104 demonstrated that doses of NRP104 up to 150 mg are safe and produce effects equal to or less than 40 mg of immediate release d-amphetamine. When compared with those of d-amphetamine, diethylproion produced effects qualitatively similar to those of d-amphetamine but were significantly less potent. Intravenous and subcutaneous routes diethylpropion was less potent as compared to oral route (Jasinski et al; 1974). This larger study is designed to compare the abuse potential of NRP104 with the Schedule II d-amphetamine sulfate and the Schedule IV diethylpropion hydrochloride. Data collected from this study will be used to evaluate the abuse potential of NRP104.

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male or female subject is 18 to 55 years of age, inclusive.
  • Except for women who are post menopausal or surgically sterile, all female subjects must have a negative urine pregnancy test at screening and at admission. They must abstain from sexual activity, or use acceptable contraceptives throughout the study, and for 30 days after the last dose of study drug. Acceptable contraceptives include double barrier method (such as condom with spermicidal gel or diaphragm with spermicidal gel), IUDs and hormonal contraceptives which must be pharmacologically effective prior to study drug exposure.
  • Meet DSM-IV criteria for the diagnosis of substance abuse.
  • Subject must be in good health and have venous access sufficient for blood collection, as determined by medical history, physical exam, and clinical labs.
  • Agree to be admitted to the inpatient research unit for a minimum of 14 days, and will be able to complete all protocol-specified assessments.
  • Able to understand that they can withdraw from the study at any time.
  • Minimum reading level of Grade Six as determined by the REALM test, at the investigator's discretion.
  • Subject must voluntarily consent to participate in this study.
  • Able to swallow the study medication whole.

Exclusion Criteria:

  • History of clinically significant gastrointestinal, renal, hepatic, endocrine, oncologic, hematologic, neurologic, psychologic, immunologic or pulmonary disorders; or cardiovascular disease, tuberculosis, epilepsy, diabetes, psychosis, glaucoma, or any condition which in the opinion of the Investigator would jeopardize the safety of the subject or impact study results or prevent the subject from completing the study.
  • Presence or history of any medically diagnosed, clinically significant Axis I psychiatric disorders other than substance abuse (including bipolar disorder, any psychotic disorder, and Tourette's disorder or family history of Tourette's).
  • Serious suicidal risk determined by the investigator.
  • Presence of a severe learning difficulty or mental retardation, or any condition that would interfere with participation or completion of the study.
  • History of allergic or adverse response or hypersensitivity to d-amphetamine or NRP104.
  • Participation in a previous clinical trial within 30 days prior to study initiation.
  • Blood loss, donation of one pint or more, or plasma donation within 60 days prior to study initiation.
  • Clinically significant abnormalities at screening or admission on results of ECG or lab tests, including lab deviations requiring acute medical intervention or further medical attention.
  • Treated with a monoamine oxidase inhibitor, currently or within 13 days of initiation of the study medication.
  • Require any of the following medications: clonidine or other alpha-2 adrenergic receptor agonists, tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs) theophylline, coumarin anticoagulants, or anticonvulsants; or have taken an SSRI in the 35 days before initiation of the study medication.
  • Currently physically dependent on benzodiazepines as determined by clinical evaluation and/or urine drug screen at screening.
  • Currently physically dependent on opiates as determined by naloxone challenge.
  • Currently physically dependent on alcohol as determined by clinical evaluation or has a confirmed positive Breathalyzer test at screening or admission.
  • Preexisting severe gastrointestinal narrowing.
  • Use of any prescription medications (except birth control) within 14 days of admission, or will require any prescription medications, or any over-the-counter (OTC) medications (other than acetaminophen), or herbal supplements or vitamins during the study.
  • Positive urine pregnancy test at screening or admission.
  • Female subject is pregnant or lactating.
  • Related to any person directly or indirectly involved with the conduct of the study or currently participating in the study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00248092

Locations
United States, Maryland
Johns Hopkins Bayview Medical Center, Clinical Studies Program
Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
New River Pharmaceuticals
Investigators
Principal Investigator: Donald R. Jasinski, MD Johns Hopkins University
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00248092     History of Changes
Other Study ID Numbers: NRP104.A03
Study First Received: November 1, 2005
Last Updated: November 1, 2007
Health Authority: United States: Food and Drug Administration

Keywords provided by New River Pharmaceuticals:
d-Amphetamine
Diethylpropion
Diethylpropion Hydrochloride
Attention Deficit Hyperactivity Disorder
Attention Deficit Disorders with Hyperactivity
Attention Deficit Hyperactivity Disorders
Amphetamine Abuse
Amphetamine Dependence
Amphetamine Addiction
Amphetamine Users
Drug Abuse
Drug Addiction
Drug Dependence
Drug Habituation
Drug Use Disorders
Substance Abuse
Substance Dependence
Substance Use Disorders
Drug Usage
Substance Addiction

Additional relevant MeSH terms:
Amphetamine-Related Disorders
Attention Deficit Disorder with Hyperactivity
Disease
Hyperkinesis
Substance-Related Disorders
Attention Deficit and Disruptive Behavior Disorders
Chemically-Induced Disorders
Dyskinesias
Mental Disorders
Mental Disorders Diagnosed in Childhood
Nervous System Diseases
Neurologic Manifestations
Pathologic Processes
Signs and Symptoms

ClinicalTrials.gov processed this record on October 22, 2014