Text Size

Optimizing Antibiotic Use in Long Term Care

This study has been completed.
Sponsor:
Information provided by:
Agency for Healthcare Research and Quality (AHRQ)
ClinicalTrials.gov Identifier:
NCT00243360
First received: October 21, 2005
Last updated: NA
Last verified: October 2005
History: No changes posted
  Purpose

The purpose of this study was to determine if a multi-faceted intervention to implement diagnostic and therapeutic algorithms for management of suspected urinary infection in nursing home residents could reduce antibiotic prescribing for urinary indications in this population.


Condition Intervention
Urinary Tract Infection, Antibiotic Use
 Behavioral: diagnostic and treatment clinical algorithms

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Educational/Counseling/Training
Official Title: Optimizing Antibiotic Use in Long Term Care

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Agency for Healthcare Research and Quality (AHRQ):

Primary Outcome Measures:
  • Antimicrobial prescriptions

Secondary Outcome Measures:
  • Urinary cultures,
  • hospitalizations, deaths

Study Start Date: January 2001
Estimated Study Completion Date: July 2003
Detailed Description:

Antibiotic use is intense in nursing homes and frequently inappropriate when prescribed for urinary indications. Evidence from randomized controlled trials suggests that treatment of asymptomatic bacteriuria, the presence of bacteria in the urine in the absence of urinary symptoms, is not beneficial. Despite this, one in three prescriptions for urinary indications are for asymptomatic bacteriuria. To improve antibiotic prescribing in this setting we conducted a cluster randomized trial of a strategy to implement diagnostic and treatment algorithms for urinary infection. 24 nursing homes were randomized to either the intervention (implemented at the nursing home level using a multi-faceted approach: small group interactive sessions for nurses, one-on-one interviews for physicians, videotapes, written material, and outreach visits) or to usual care.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Individuals- all residents eligible

  2. Nursing homes

    • Free standing long term care facilities with >100 beds
    • No stated policy for diagnosis or treatment of urinary tract infections
    • The facility agrees to refrain from introducing new strategies for antibiotic utilization or clinical pathways during study

Exclusion Criteria:

-

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00243360

Locations
Canada, Ontario
McMaster University
Hamilton, Ontario, Canada, L8N 3Z5
Sponsors and Collaborators
Agency for Healthcare Research and Quality (AHRQ)
Investigators
Principal Investigator: Mark B Loeb, MD MSc FRCPC McMaster University
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00243360     History of Changes
Other Study ID Numbers: U18 HS11113-01
Study First Received: October 21, 2005
Last Updated: October 21, 2005
Health Authority: United States: Federal Government
Canada: Health Canada

Keywords provided by Agency for Healthcare Research and Quality (AHRQ):
Urinary tract infections,
antibiotic use,
long term care facilities

Additional relevant MeSH terms:
Urinary Tract Infections
Infection
Urologic Diseases
Anti-Bacterial Agents
 Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions

ClinicalTrials.gov processed this record on May 16, 2013