Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2008 by Children's Healthcare of Atlanta.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by (Responsible Party):
Children's Healthcare of Atlanta
ClinicalTrials.gov Identifier:
NCT00238810
First received: October 12, 2005
Last updated: March 14, 2012
Last verified: July 2008
  Purpose

The purpose of this study is to assess brain natriuretic peptide levels to evaluate the relationship of those levels with the diagnosis of congenital cardiac disease, operation performed, post-operative course, and outcome.


Condition
Congenital Heart Disease

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Retrospective Evaluation of Serum B-type Natriuretic Peptide Hormone Levels in Post-operative Patients and the Relationship of BNP Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome

Resource links provided by NLM:


Further study details as provided by Children's Healthcare of Atlanta:

Estimated Enrollment: 20
Study Start Date: April 2005
Detailed Description:

Three types of natriuretic peptides (NP) have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The NP family elicits a number of vascular, renal and endocrine effects that help to maintain blood pressure and extracellular fluid volume. These effects are mediated by the specific binding of NP to cell surface receptors that have been characterized, purified and cloned from cells of the vasculature, kidney, adrenal gland and brain. There are 3 subtypes of NP receptors: type A natriuretic peptide receptor (NPRA), type B natriuretic peptide receptor (NPRB), and type C natriuretic peptide receptor (NPRC). All 3 subtypes affect cellular second messenger activity. The literature currently does not define the levels of b-type natriuretic peptide (BNP) in children with congenital heart disease undergoing surgery.

The investigator wishes to perform a retrospective chart review to define BNP levels in the pediatric cardiac defect population and to evaluate the relationship of those levels with cardiac diagnosis, operation performed, post-operative course and outcome. The investigator will collect the following information from the medical record:

  • Laboratory: BNP levels, serum pH, lactic acid, Co-ox, CBC, Chemistry
  • Diagnosis
  • Surgical Procedure
  • Incidence of re-operation
  • Length of ICU Stay
  • Length of Hospital Stay
  • Complications
  • Length of Ventilation (how many days on the ventilator)
  • Medications
  • Cross Clamp Time
  • Bypass Time
  • Echocardiogram data
  • Cardiac Catheterization Data
  • Vital Signs
  • Monitored Hemodynamic Measures
  • Final outcome (discharged or death)
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with congenital heart defects

Criteria

Inclusion Criteria:

  • Congenital heart defect

Exclusion Criteria:

  • Patients without congenital heart defects
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00238810

Locations
United States, Georgia
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Children's Healthcare of Atlanta
Investigators
Principal Investigator: Alecia Wang, MD Emory University Cardiac Fellow at Children's Healthcare of Atlanta
  More Information

Publications:
Responsible Party: Children's Healthcare of Atlanta
ClinicalTrials.gov Identifier: NCT00238810     History of Changes
Other Study ID Numbers: 05.068
Study First Received: October 12, 2005
Last Updated: March 14, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Children's Healthcare of Atlanta:
BNP
Pediatrics
Congenital heart disease
b-type natriuretic peptide

Additional relevant MeSH terms:
Heart Diseases
Heart Defects, Congenital
Cardiovascular Diseases
Cardiovascular Abnormalities
Congenital Abnormalities
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs
Pharmacologic Actions
Cardiovascular Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on September 30, 2014