Vitamin D Deficiency: Bone Loss and Vascular Dysfunction
To learn if there is a connection between low vitamin D level and hardening of the arteries.
Procedure: 10 vit. D deficient subjects take vit. D for 3 months.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Vitamin D Deficiency: Bone Loss and Vascular Dysfunction|
- to determine if differences exist in vascular compliance and carotid artery intima media thickness between individuals with normal and low vitamin D levels
- to evaluate correlation of markers of vascular disease and boen disease between individuals with normal and low vitamin D
- to quantify the effect of Vitamin D replacement on vascular compliance and markers of bone loss and vascular disease.
- Vitamin D at the end of 3 months of supplementation.
|Study Start Date:||April 2004|
|Study Completion Date:||September 2007|
Osteoporosis and vascular disease are two of the most common disorders affecting postmenopausal women. A potential association, beyond aging, has long been speculated. Our previous study revealed evidence of loss of vascular compliance in postmenopausal women with lower bone density, suggesting women with lower bone density had "stiffer" blood vessels. This proposal further investigates that association and a potential role of vitamin D deficiency as a possible common link between both bone loss and "hardening of the arteries".
Please refer to this study by its ClinicalTrials.gov identifier: NCT00235586
|United States, Kansas|
|University of Kansas Medical Center|
|Kansas City, Kansas, United States, 66160|
|Principal Investigator:||Leland Graves, III, MD||University of Kansas|