Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations
Patients scheduled for primary total hip replacement needs postoperative pain treatment: i.e. morphine. Unfortunately morphine has side-effects: nausea, vomiting, sedation and dizziness, which is unpleasant for the patients and sometimes keeps them at bed longer time than needed. We investigate in new combinations of analgesics for postoperative pain, hoping to minimize the need for morphine and improve the patients pain score after operation.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||Effect of Paracetamol Versus Paracetamol Combined With Pregabalin Versus Paracetamol Combined With Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients Scheduled for a Primary Total Hip Replacement|
- The total amount of morphine needed postoperatively from 0-4 h, and 0-24 h, administered by a patient controlled pain treatment. (PCA)
- Pain score (VAS) at rest and at mobilisation.
- Postoperative nausea and vomiting.
- All measurements are taken at 2,4 and 24 h postoperatively
|Study Start Date:||October 2005|
|Study Completion Date:||June 2007|
We investigate the effect of paracetamol versus paracetamol + pregabalin versus paracetamol + pregabalin + dexamethasone on pain and morphine usage in the first 24 hours postoperatively in patients getting a new hip alloplastic.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00235261
|Department of anaesthesiology; Hoersholm Sygehus|
|Hoersholm, Frederiksborg Amt, Denmark, 2970|
|Study Chair:||Ole Mathiesen, MD||Department of Anaesthesiology, Copenhagen University Hospital in Glostrup, 2600 Glostrup, Denmark|
|Principal Investigator:||Lars Steen Jacobsen, MD||Departmentof Anaesthesiology; Hørsholm Sygehus; Usserød Kongevej 102; 2970 Hørsholm; Denmark|