TDI Preejection Velocities and Myocardial Viability
Recruitment status was Recruiting
The purpose of the study is to test accuracy of positive preejection velocity to predict left ventricular remodeling and long-term prognosis after revascularization in 200 patients with chronically dysfunctional myocardium. Patients will be followed for 3 years.
Our hypothesis is that tissue-Doppler-derived analysis of positive preejection velocity allows to select optimal responders to revascularization; it means individuals with the greatest benefit in terms of LV remodeling and long-term prognosis.
|Study Design:||Observational Model: Case Control
Time Perspective: Longitudinal
|Official Title:||TDI-Derived Myocardial Preejection Velocities in Patients With Chronic Ischemic Left Ventricular Dysfunction Undergoing Surgical Revascularization|
|Study Start Date:||January 2005|
|Estimated Study Completion Date:||December 2009|
The objective of the project is to study clinical and prognostic value of new echocardiographic technique, so called positive preejection velocity (+VIC), in patients with chronic ischemic left ventricular (LV) dysfunction indicated for revascularization. Pilot studies has shown high accuracy of pulsed Tissue Doppler imaging (TDI)-derived resting pattern of +VIC to detect viable myocardium in patients with both acute myocardial infarction and chronically dysfunctional myocardium. The aim of the project is to test accuracy of +VIC to predict LV remodeling and long-term prognosis after revascularization in patients with chronically dysfunctional myocardium. Study population will consist of two groups of patients with stable ischemic LV dysfunction: group A- patients indicated for revascularization (n=200), group B- matched control group treated conservatively (case-control design) (n=100). All patients will be followed for 3 years. Endpoints include: 1) LV remodeling at 6 and 24 months and 2) MACE at 6, 12 and 36 months follow-up. Our hypothesis is that TDI-derived analysis of +VIC allows to select optimal responders to revascularization; it means individuals with the greatest benefit in terms of LV remodeling and long-term prognosis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00231205
|Contact: Martin Penicka, MD, PhD||+420 26716 firstname.lastname@example.org|
|Contact: Petr Tousek, MD||+420 26716 email@example.com|
|III. Internal-cardiological clinic, 3rd Medical Faculty, Charles University||Recruiting|
|Prague, Czech Republic, 100 00|
|Contact: Martin Penicka, MD, PhD +420 26716 2724 firstname.lastname@example.org|
|Contact: Petr Tousek, MD +420 26716 2724 email@example.com|
|Principal Investigator: Martin Penicka, MD, PhD|
|Principal Investigator:||Martin Penicka, MD, PhD||Charles University, Prague, Czech Republic|