The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation

This study has been completed.

First Received on September 21, 2005. Last Updated on September 16, 2011 History of Changes

Sponsor:	Children's Mercy Hospital Kansas City
Collaborator:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by (Responsible Party):	Children's Mercy Hospital Kansas City
ClinicalTrials.gov Identifier:	NCT00224926

Purpose

To explore carrier and infection status of T.tonsurans tinea capitis and characterize the host-pathogen interaction as it relates to the disease presentation. The general hypothesis for this study is as follows: the type of genotypic and phenotypic variant to which a child is exposed accounts for the presentation status observed in Trichophyton tonsurans infection.The global outcome of this investigation is to reveal potential new drug targets designed to improve treatment outcomes in these children.

Condition	Intervention
Tinea Capitis	Procedure: Scalp Brushing

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	The Natural Course of Trichophyton Tonsurans Carriage and Infection: A Molecular and Biochemical Evaluation

Resource links provided by NLM:

MedlinePlus related topics: Tinea Infections

U.S. FDA Resources

Further study details as provided by Children's Mercy Hospital Kansas City:

Biospecimen Retention: Samples With DNA

fungal scalp cultures

Enrollment:	446
Study Start Date:	September 2003
Study Completion Date:	September 2005

Intervention Details:

sterile, soft-head toothbrush massaged on scalp

Detailed Description:

Tinea capitis is an overwhelmingly prevalent disease of childhood estimated to be present in approximately 1 in 20 children at any point in time with an equal number of children serving as carriers of the fungal pathogen. Despite the widespread nature of the disease, the natural course of the infection remains incompletely described. The study will be driven by the following hypothesis: the type of genotypic and phenotypic variant to which a child is exposed accounts for the presentation status observed in Trichophyton tonsurans infection.

A fungal scalp culture will be acquired from all participants using a brush culture technique. Samples will be collected once a month over a two year time period.

Eligibility

Ages Eligible for Study:	2 Years to 5 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

preschool aged children

Criteria

Inclusion Criteria:

Preschool aged children will be eligible.

Exclusion Criteria:

None

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00224926

Locations

United States, Missouri
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108

Sponsors and Collaborators

Children's Mercy Hospital Kansas City

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Investigators

Principal Investigator:

Susan Rahman, PharmD

Children's Mercy Hosptials and Clinics

More Information

Additional Information:

Pediatric Pharmacology Research Unit Website This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party:	Children's Mercy Hospital Kansas City
ClinicalTrials.gov Identifier:	NCT00224926 History of Changes
Other Study ID Numbers:	PPRU 10704
Study First Received:	September 21, 2005
Last Updated:	September 16, 2011
Health Authority:	United States: Federal Government

Keywords provided by Children's Mercy Hospital Kansas City:

Tinea Capitis

Additional relevant MeSH terms:

Tinea
Tinea Capitis
Dermatomycoses
Skin Diseases, Infectious

Infection
Mycoses
Skin Diseases
Scalp Dermatoses

ClinicalTrials.gov processed this record on February 12, 2012