Comparison Between Volume Controlled Ventilation and Pressure Controlled Ventilation
To assess the potential benefits on mechanical ventilation plateau pressure of pressure controlled mode versus volume controlled mode for laparoscopic bariatric surgery in obese patients (BMI > 35). High plateau pressures encountered in obese patients due to their reduced pulmonary compliance could be lowered using pressure controlled mechanical ventilation.
Reduced Lung Compliance.
Procedure: Mechanical Ventilation
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment
- Plateau pressures generated by mechanical ventilation after 45 minutes of pneumoperitoneum.
- Comparison of PaO2 and PaCO2 after 45 minutes of pneumoperitoneum and after 2 hours spent in post-anesthesia care unit ; comparison of total respiratory resistances and peak flow generated between the 2 modes.
|Study Start Date:||January 2005|
|Estimated Study Completion Date:||June 2005|
All patients are over 18 years old and give their inform consent after approval of the study protocol by an ethic committee. Anesthesia is standardized and all patients are intubated. Precise protocols are used to perform pressure and volume controlled ventilation in order to regulate End-Tidal CO2 between 33 and 35 mmHg. Primary goal is comparison of plateau pressures observed in the 2 ventilation modes after 45 minutes of pneumoperitoneum. Secondary goals are : comparison of PaO2 and PaCO2 after 45 minutes of pneumoperitoneum and after 2 hours spent in post-anesthesia care unit ; comparison of total respiratory resistances and peak flow generated between the 2 modes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00224653
|Georges Pompidou European Hospital|
|Paris, Ile de France, France, 75908 cedex 15|
|Principal Investigator:||Philippe CADI, MD||Assistance Publique - Hôpitaux de Paris|