KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

This study has been completed.
Sponsor:
Collaborators:
Direction Régionale de la Recherche Clinique D'ILE DE FRANCE
Clinical Research Unit
European Georges Pompidou Hospital
Information provided by:
Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier:
NCT00224588
First received: September 16, 2005
Last updated: April 12, 2006
Last verified: September 2005
  Purpose

We assessed the effects of the N Methyl aspartate receptor antagonist Ketamine on long-term post thoracotomy pain. We hypothesized that ketamine could prevent supersensitization of the central nervous system involved in this chronic neuropathic pain.


Condition Intervention Phase
Ketamine
Chronic Post Thoracotomy Pain
Thoracotomy
Pain
Neuralgia
Drug: Ketamine (or placebo : isotonic saline solution)
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

Resource links provided by NLM:


Further study details as provided by Assistance Publique - Hôpitaux de Paris:

Primary Outcome Measures:
  • Long term (2 months) post thoracotomy pain was assessed using a french equivalent of the Mc Gill Pain score and pain area measurements in both groups

Secondary Outcome Measures:
  • Analogic pain scores at rest and after coughing

Estimated Enrollment: 80
Study Start Date: January 2003
Estimated Study Completion Date: May 2005
Detailed Description:

In this clinical, randomized prospective study, peri operative administration of ketamine was compared to placebo on long term post thoracotomy pain after a 2 months follow up period.

  Eligibility

Ages Eligible for Study:   80 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients eligible for thoracotomy or pneumectomy

Exclusion Criteria:

-

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00224588

Locations
France
Georges Pompidou European Hospital
Paris, Ile de France, France, 75015
Sponsors and Collaborators
Assistance Publique - Hôpitaux de Paris
Direction Régionale de la Recherche Clinique D'ILE DE FRANCE
Clinical Research Unit
European Georges Pompidou Hospital
Investigators
Principal Investigator: Thierry GUENOUN, MD Assistance Publique - Hôpitaux de Paris
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00224588     History of Changes
Other Study ID Numbers: P990911, CRC99029
Study First Received: September 16, 2005
Last Updated: April 12, 2006
Health Authority: France: Ministry of Health

Keywords provided by Assistance Publique - Hôpitaux de Paris:
Ketamine
Chronic post thoracotomy pain
NMDA
Post operative

Additional relevant MeSH terms:
Ketamine
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on September 18, 2014