Text Size
Trial record 3 of 6 for:    "Arrhythmogenic right ventricular dysplasia"
Previous Study | Return to List | Next Study

Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2003 by University of Heidelberg.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University of Heidelberg
ClinicalTrials.gov Identifier:
NCT00221832
First received: September 14, 2005
Last updated: January 12, 2010
Last verified: October 2003
History of Changes
  Purpose

The aim of this study is the identification of familial congenital arrhythmogenic disorders and their clinical follow-up.


Condition
Long QT Syndrome
Hypertrophic Cardiomyopathy
Arrhythmogenic Right Ventricular Dysplasia

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases

Resource links provided by NLM:

MedlinePlus related topics: Cardiomyopathy
U.S. FDA Resources

Further study details as provided by University of Heidelberg:

Biospecimen Retention:   Samples With DNA

no biospecimens are to be retained.


Estimated Enrollment: 300
Study Start Date: October 2003
Estimated Study Completion Date: December 2011
Detailed Description:

Molecular genetic screening in patients with:

  • supraventricular
  • ventricular arrhythmia
  • syncopes of unknown origin and/or suspicion of an arrhythmogenic origin
  • family members of patients with sudden cardiac death and aborted sudden cardiac death

Examination of patients includes routine testing like electrocardiogram (ECG), sequential ECGs, exercise testing, invasive electrophysiological stimulation, cardiac magnetic resonance imaging, intravenous drug challenge for identification/exclusion of eg Brugada syndrome. Examples are patients with Long QT Syndrome, Short QT Syndrome, Brugada Syndrome, familial atrial fibrillation, WPW-syndrome, arrhythmias due to familial hypertrophic cardiomyopathy or arrhythmogenic right ventricular dysplasia. Blood samples are taken for further molecular genetic screening.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Consecutive patient sampling with history of syncope, aborted SCD, familial sudden cardiac death, high suspicion of familial cardiac arrhythmias.

Criteria

Inclusion Criteria:

  • Patients with a history of syncope, abnormal ECG and suspicion of an arrhythmogenic disease
  • Patients with long QT syndrome
  • Patients with short QT syndrome, shortened QT intervals, borderline shortened QT intervals
  • Patients with Brugada syndrome
  • Patients with hypertrophic cardiomyopathy
  • Patients with arrhythmogenic right ventricular dysplasia

Exclusion Criteria:

  • Inability to understand study protocol
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00221832

Contacts
Contact: Christian Wolpert, MD +49-621-383-2206 christian.wolpert@med.ma.uni-heidelberg.de
Contact: Rainer Schimpf, MD +49-621-383-2206 rainer.schimpf@med.ma.uni-heidelberg.de

Locations
Germany
University Hospital Mannheim, I. Department of Medicine Recruiting
Mannheim, Germany, 68167
Contact: Christian Wolpert, MD     +49-621-3832206     christian.wolpert@med.ma.uni-heidelberg.de    
Contact: Rainer Schimpf, MD     +49-621-3832206     rainer.schimpf@med.ma.uni-heidelberg.de    
Principal Investigator: Christian Wolpert, MD            
Sponsors and Collaborators
University of Heidelberg
Investigators
Study Director: Martin Borggrefe, Prof., MD I. Department of Medicine-Cardiology
  More Information

No publications provided

Responsible Party: Prof. C. Wolpert, I. Department of Medicine-Cardiology, University Hospital Mannheim, . Department of Medicine-Cardiology, University Hospital Mannheim
ClinicalTrials.gov Identifier: NCT00221832     History of Changes
Other Study ID Numbers: 0261.5
Study First Received: September 14, 2005
Last Updated: January 12, 2010
Health Authority: Germany: Ethics Commission

Keywords provided by University of Heidelberg:
Long QT Syndrome
Hypertrophic cardiomyopathy
arrhythmogenic right ventricular dysplasia
Short QT Syndrome
Brugada Syndrome

Additional relevant MeSH terms:
Arrhythmogenic Right Ventricular Dysplasia
Cardiomyopathy, Hypertrophic
Hypertrophy
Long QT Syndrome
Cardiomyopathies
Heart Diseases
Cardiovascular Diseases
Aortic Stenosis, Subvalvular
 Aortic Valve Stenosis
Heart Valve Diseases
Pathological Conditions, Anatomical
Arrhythmias, Cardiac
Heart Defects, Congenital
Cardiovascular Abnormalities
Congenital Abnormalities
Pathologic Processes

ClinicalTrials.gov processed this record on May 19, 2013