Weight Changes in Parkinsonian Patients, Treated With Deep Brain Stimulation

• Measurement of energy expenditure with indirect calorimetry in open chamber: at rest in the morning, without 24h-dopaminergic treatment, and after dopaminergic treatment intake; and post prandial thermogenesis after a test meal. [ Time Frame: After surgery and at 3 months ] [ Designated as safety issue: No ]
  

• Weight gain [ Time Frame: At visit 1 and at 3 months ] [ Designated as safety issue: No ]
  
• increase of energy intake [ Time Frame: At visit 1 and at 3 months ] [ Designated as safety issue: No ]
  
• leptin, glucose, insulin blood levels [ Time Frame: At visite 1 and at 3 months ] [ Designated as safety issue: No ]
  
• cognitive and psychological assessments [ Time Frame: before surgery and after 3 months ] [ Designated as safety issue: No ]
  
• UDPRS scale [ Time Frame: before surgery and after 3 months ] [ Designated as safety issue: No ]
  

The aim of this trial is to verify that neurostimulated parkinsonian patients gain weight and to study its link with an energetic balance change.

Twenty parkinsonian patients will be randomised : the delay between inclusion and neurostimulation wil be lengthened 3 months for one group, compared to the second one. The energy expenditure, at rest and after ingestion of a test meal, will be compared between the group of patients that had been neurostimulated and the group whose intervention has been postponed. Weight changes, energy intake, leptin level, neurophysiological parameters will be compared between both groups, and the nature and repartition of the weight gain will be assessed in the neurostimulated group. An eventual link between motor factors, pharmacological factors, and gain weight will be studied.