Home Treatment of Pulmonary Embolism
Recruitment status was Active, not recruiting
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Purpose
The best management in selected patients of pulmonary Embolism (PE) should be at home. The efficacy and safety treatment´s at home versus at hospital should be similar and quality of life should be better. Our purpose is to demostrate that Low weight molecular heparin (LWMH) at home for PE is at least as effective and safe at home as at hospital
| Condition | Intervention | Phase |
|---|---|---|
|
Pulmonary Embolism |
Behavioral: treatment at home |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Cooperative Investigation Plan for Home Treatment of Pulmonary Embolism |
- -Thromboembolic recurrences
- -Bleeding Complications
- -Deaths
- -Quality of life
| Study Start Date: | December 2004 |
| Estimated Study Completion Date: | August 2005 |
In order to carry out the Cooperative Investigation Plan for home treatment of pulmonary embolism, a network of multidisciplinary groups was built with the participation of 10 groups, distributed in 6 different regions and integrated within the Spanish Society of Pneumology and Thoracic Surgery (SEPAR).
Those groups will share a database integrated in the Spanish Registry on Thromboembolic Disease (RIETE), which is a project already being carried out and in which many of the groups of the network already participate.
The research project will be a study developed in two phases. In the first phase, predictive profiles for a favourable progression of the disease in patients with pulmonary embolism will be studied using the actual management of the disease with the current assistance model.
In the second phase, a randomized study comparing the efficacy and safety of two models of home treatment ( discharge from hospital during the first 72 hours after the diagnosis of PE and discharge from hospital during the first 5 days) in patients previously selected, according to predefined criteria which were modified on the basis of the results of phase I versus the current assistance model will be developed
The results will be measured in terms of efficacy, safety, economic burden, and quality of life in both models (at home and at hospital).
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- The consecutive outpatients subjects diagnosed of PE at 10 different Spanish hospitals.
- A score of 2 or under in our prediction rule (risk score for short-term)
- Signed written Informed consent
Exclusion Criteria:
- A score over 2 in our prediction rule
- Patients with a PE requiring thrombolysis or surgical thrombectomy
- Patients with right ventricular dyskinesia in echocardiography at 48 hours from heparin therapy. (It is not necessary echocardiography for the model of discharge at 5 days)
- Troponin level over 0,1 g/L
- Patiens requiring oxygen therapy or under 93% in oxygen saturation level.
- Patients requiring intravenous analgesic therapy
- Patients with some medical or surgical conditions requiring to stay at hospital
- Patients with advanced chronic cardiovascular diseases (dyspnea III-IV NYHA)
- Patients with advanced chronic respiratory diseases (several COPD criteria of GOLD with FEV1< 50%)
- Documented congenital or acquired bleeding tendency /disorder (s)
- Documented current ulceration or angiodysplastic gastrointestinal disease
- Hemorrhagic stroke or recent (< 3 months prior to randomization) brain, spinal, or ophthalmological surgery.
- Recent surgery < 3 days
- Pregnancy
- Several Obesity (CMI over 30)
- Patients could not complete the treatment at home.
- Exclusion criteria related to study procedures
- Life expectancy < 3 months
Contacts and Locations| Spain | |
| Pneumology Service of HVR | |
| Seville, Spain, 41013 | |
| Study Chair: | Remedios Otero, MD | Pneumology Service of Virgen de Rocio Hospital (Spain) |
| Principal Investigator: | Fernando Uresandi, MD | Pneumology Service.Cruces Hospital (Spain) |
| Principal Investigator: | David Jimenez, MD | Pneumology Service. Ramon y Cajal Hospital (Spain) |
| Principal Investigator: | Miguel A. Cabezudo, MD | Pneumology Service. H. Asturias (Spain) |
| Principal Investigator: | Francisco Conget, MD | Pneumology Service. Clinic Hospital of Zaragoza (Spain) |
| Principal Investigator: | Dolores Nauffal, MD | Pneumology Service. La Fe Hospital (Spain) |
| Principal Investigator: | Mikel Oribe, MD | Pneumology Service. Galdakao Hospital (Spain) |
| Principal Investigator: | Jose L. Lobo, MD | Pneumology Service. Txagorritxu Hospital (Spain) |
| Principal Investigator: | Fulgencio Gonzalez, MD | Pneumology Service. 12 de Octubre Hospital (Spain) |
| Principal Investigator: | Elena Laserna, MD | Pneumology Service. S.Juan de Dios Hospital (Spain) |
More Information
Additional Information:
No publications provided by Carlos III Health Institute
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| ClinicalTrials.gov Identifier: | NCT00214929 History of Changes |
| Other Study ID Numbers: | PIO30192 |
| Study First Received: | September 16, 2005 |
| Last Updated: | December 8, 2005 |
| Health Authority: | Spain: Ministry of Health |
Keywords provided by Carlos III Health Institute:
|
Pulmonary Embolism Therapy Home Nursing Economics |
Additional relevant MeSH terms:
|
Embolism Pulmonary Embolism Embolism and Thrombosis Vascular Diseases |
Cardiovascular Diseases Lung Diseases Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on May 16, 2013