Methotrexate and Cyclosporine in Treatment of Early Rheumatoid Arthritis
To investigate whether cyclosporine, added to methotrexate and steroid, increases the possibility of inflammatory management early in the disease; furthermore to investigate the possible steroid-sparing effect of cyclosporine in patients with recently diagnosed rheumatoid arthritis.
Drug: Intraarticular betamethasone
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||Combination Treatment With Methotrexate and Cyclosporine in Early Rheumatoid Arthritis.|
- ACR20 response
- ACR remission (modified)
- Cumulated dose of glucocorticoids
- Development of erosions
- Development of osteopenia
|Study Start Date:||October 1998|
|Estimated Study Completion Date:||November 2007|
Design: Multicentre, prospective, randomised, double-blind study with parallel design.
Selection of patients: Patients with recently diagnosed rheumatoid arthritis (less than 6 months of persistent synovitis).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00209859
|Hvidovre University Hospital|
|Hvidovre, Denmark, 2650|
|Principal Investigator:||Merete L Hetland, MD, PhD||Hvidovre Univervsity Hospital|
|Principal Investigator:||Kim Hørslev-Petersen, MD, DSc||Rheumatism Hospital Graasten|